HitPredict

Interactor 1: DERL1 (Q9BUN8)
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Gene: DERL1

Interactor 2: RTN4 (Q9NQC3)
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Gene: RTN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22119785, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 251 Hs			1 1192
+	Hs
		1326101 DERL2_HUMAN (8-249): 5.87e-78: 236: 34.30		RTN4_HUMAN (1-1192): 3.85e-113: 383: 100.00
+	Hs
		307109 DERL1_HUMAN (1-251): 9.26e-89: 264: 100.00		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		1087791 DERL1_HUMAN (1-251): 9.26e-89: 264: 100.00		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36
+	Hs
		307113 DERL2_HUMAN (8-249): 5.87e-78: 236: 34.30		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		1087794 DERL2_HUMAN (8-249): 5.87e-78: 236: 34.30		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36
+	At
		1227354 RBL15_ARATH (4-247): 7.51e-57: 188: 18.56		RTNLD_ARATH (992-1192): 1.36e-70: 238: 22.75
+	At
		1227355 RBL15_ARATH (4-247): 7.51e-57: 188: 18.56		RTNLH_ARATH (990-1188): 8.95e-61: 210: 18.54