HitPredict

Interactor 1: IMA4 (O00505)
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
Gene: KPNA3

Interactor 2: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	20562864, 21888893
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 521 Hs			1 191
+	Hs
		134845 IMA3_HUMAN (1-521): 1.68e-160: 468: 85.80		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		134888 IMA3_HUMAN (1-521): 1.68e-160: 468: 85.80		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		131416 IMA4_HUMAN (1-521): 9.9e-164: 476: 100.00		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		134876 IMA3_HUMAN (1-521): 1.68e-160: 468: 85.80		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		800322 IMA1_HUMAN (3-521): 1.35e-143: 425: 48.49		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		238666 IMA7_HUMAN (1-520): 9.33e-140: 415: 46.54		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		853239 IMA1_HUMAN (3-521): 1.35e-143: 425: 48.49		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		238657 IMA7_HUMAN (1-520): 9.33e-140: 415: 46.54		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	At
		1276955 IMPA1_ARATH (1-521): 7.19e-158: 461: 43.34		LHP1_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		984992 IMPA1_ARATH (1-521): 7.19e-158: 461: 43.34		Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		97779 IMPA2_ARATH (1-521): 8.29e-157: 459: 43.28		Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		97806 IMPA2_ARATH (1-521): 8.29e-157: 459: 43.28		LHP1_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		285377 IMPA4_ARATH (1-521): 4.97e-154: 452: 43.49		Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		285382 IMPA4_ARATH (1-521): 4.97e-154: 452: 43.49		LHP1_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		1276959 IMPA6_ARATH (1-521): 3.79e-153: 449: 43.68		LHP1_ARATH (13-104): 2.12e-16: 78: 33.68
+	At
		984993 IMPA6_ARATH (1-521): 3.79e-153: 449: 43.68		Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68