HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37071664
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1834 Hs			1 628
+	Hs
		297648 SLX4_HUMAN (1-1834): 0: 1473: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		1314307 SLX4_HUMAN (1-1834): 0: 1473: 100.00		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		1314318 SLX4_HUMAN (1-1834): 0: 1473: 100.00		ZMIZ2_HUMAN (81-619): 2.54e-79: 271: 20.46
+	Hs
		297605 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		1129647 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71