Protein: PIAS4
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)

Gene: PIAS4
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q8N2W9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001942 - hair follicle development
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

964366

SUMO2
Small ubiquitin-related modifier 2

5

20

Small-scale

0.924

High

993650

UBC9
SUMO-conjugating enzyme UBC9

5

14

Small-scale

0.916

High

1324618

NEMO
NF-kappa-B essential modulator

5

4

Small-scale

0.702

High

414194

P53
Cellular tumor antigen p53

4

10

Small-scale

0.685

High

487524

PARP1
Poly [ADP-ribose] polymerase 1

3

3

Small-scale

0.681

High

1106607

SMAD4
Mothers against decapentaplegic homolog 4

3

16

Small-scale

0.669

High

1314307

SLX4
Structure-specific endonuclease subunit SLX4

3

5

High-throughput

0.656

High

1324562

PIAS4
E3 SUMO-protein ligase PIAS4

1

9

Small-scale

0.647

High

1051266

KPCZ
Protein kinase C zeta type

2

4

Small-scale

0.643

High

1039532

TOP2B
DNA topoisomerase 2-beta

2

3

Small-scale

0.639

High

1324600

CAH10
Carbonic anhydrase-related protein 10

3

0

High-throughput

0.638

High

587140

ITF2
Transcription factor 4

3

0

Small-scale

0.636

High

1014552

SMAD3
Mothers against decapentaplegic homolog 3

2

16

Small-scale

0.631

High

843756

HD
Huntingtin

2

1

High-throughput

0.631

High

542577

TOP2A
DNA topoisomerase 2-alpha

2

3

Small-scale

0.629

High

177695

SMAD7
Mothers against decapentaplegic homolog 7

2

16

Small-scale

0.627

High

1153978

SMAD1
Mothers against decapentaplegic homolog 1

2

16

Small-scale

0.627

High

957627

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.622

High

297837

PIAS2
E3 SUMO-protein ligase PIAS2

1

9

High-throughput

0.621

High

991365

SUMO1
Small ubiquitin-related modifier 1

1

20

Small-scale

0.621

High

1153833

SMAD2
Mothers against decapentaplegic homolog 2

2

16

Small-scale

0.620

High

558267

XRCC6
X-ray repair cross-complementing protein 6

1

4

Small-scale

0.618

High

559417

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.618

High

1324567

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

9

Small-scale

0.618

High

590454

GATA1
Erythroid transcription factor

2

2

Small-scale

0.611

High

284846

TADA3
Transcriptional adapter 3

2

0

High-throughput

0.609

High

142689

TRI38
E3 ubiquitin-protein ligase TRIM38

2

7

High-throughput

0.606

High

1324565

ZBT34
Zinc finger and BTB domain-containing protein 34

2

5

High-throughput

0.606

High

520201

ANDR
Androgen receptor

2

20

Small-scale

0.602

High

822754

VHL
von Hippel-Lindau disease tumor suppressor

2

0

Small-scale

0.598

High

1032766

SATB1
DNA-binding protein SATB1

2

4

Small-scale

0.595

High

939211

SUMO3
Small ubiquitin-related modifier 3

1

20

High-throughput

0.590

High

543584

ERR1
Steroid hormone receptor ERR1

2

18

Small-scale

0.586

High

577465

ETS1
Protein C-ets-1

2

14

Small-scale

0.584

High

714266

PML
Protein PML

2

10

High-throughput

0.584

High

1213954

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.580

High

1324610

LEF1
Lymphoid enhancer-binding factor 1

1

11

Small-scale

0.573

High

1324585

GFI1
Zinc finger protein Gfi-1

2

2

Small-scale

0.565

High

175473

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

4

Small-scale

0.561

High

221803

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.561

High

542114

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.561

High

675584

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.561

High

219872

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.552

High

572066

TRI27
Zinc finger protein RFP

1

7

Small-scale

0.552

High

1095707

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.541

High

211817

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

Small-scale

0.537

High

897590

KNTC1
Kinetochore-associated protein 1

1

0

Small-scale

0.537

High

1324586

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

155779

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

180870

TIF1A
Transcription intermediary factor 1-alpha

1

13

High-throughput

0.536

High

833755

KDM5C
Lysine-specific demethylase 5C

1

2

High-throughput

0.536

High

1028280

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.536

High

1139761

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

High-throughput

0.536

High

1210725

ZMYM1
Zinc finger MYM-type protein 1

1

6

High-throughput

0.536

High

1250448

MCAF1
Activating transcription factor 7-interacting protein 1

1

3

High-throughput

0.536

High

1275937

SETX
Probable helicase senataxin

1

2

High-throughput

0.536

High

1310085

MGAP
MAX gene-associated protein

1

1

High-throughput

0.536

High

1324576

XPF
DNA repair endonuclease XPF

1

2

High-throughput

0.536

High

1324578

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.536

High

1324604

SENP1
Sentrin-specific protease 1

1

2

High-throughput

0.536

High

1324613

YETS2
YEATS domain-containing protein 2

1

3

High-throughput

0.536

High

1324616

ARIP4
Helicase ARIP4

1

6

High-throughput

0.536

High

1129161

IRF3
Interferon regulatory factor 3

1

3

Small-scale

0.534

High

1324577

IRF7
Interferon regulatory factor 7

1

3

Small-scale

0.534

High

1045510

TF65
Transcription factor p65

1

7

Small-scale

0.515

High

1141214

BRD3
Bromodomain-containing protein 3

1

6

High-throughput

0.515

High

116867

I6L9F6
NEFL protein

1

8

High-throughput

0.515

High

250703

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.515

High

345196

ZMYM6
Zinc finger MYM-type protein 6

1

4

High-throughput

0.515

High

478332

HXC4
Homeobox protein Hox-C4

1

4

High-throughput

0.515

High

1053253

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

1126720

BECN1
Beclin-1

1

1

High-throughput

0.515

High

1253287

CC141
Coiled-coil domain-containing protein 141

1

5

High-throughput

0.515

High

1324563

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

2

High-throughput

0.515

High

1324569

GABP2
GA-binding protein subunit beta-2

1

2

High-throughput

0.515

High

1324570

MAGC3
Melanoma-associated antigen C3

1

2

High-throughput

0.515

High

1324571

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.515

High

1324608

KLF15
Krueppel-like factor 15

1

3

High-throughput

0.515

High

948212

ZN445
Zinc finger protein 445

1

0

High-throughput

0.513

High

1007584

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.513

High

1124118

NPAT
Protein NPAT

1

0

High-throughput

0.513

High

1150298

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.513

High

1201850

PKHG4
Puratrophin-1

1

0

High-throughput

0.513

High

1244019

ZCH12
Zinc finger CCHC domain-containing protein 12

1

0

High-throughput

0.513

High

1279287

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.513

High

1287855

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

1315022

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.513

High

1324566

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.513

High

1324574

RREB1
Ras-responsive element-binding protein 1

1

0

High-throughput

0.513

High

1324591

FANCJ
Fanconi anemia group J protein

1

0

High-throughput

0.513

High

1324596

ZN644
Zinc finger protein 644

1

0

High-throughput

0.513

High

1324597

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

1324599

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

163803

TCRG1
Transcription elongation regulator 1

1

3

High-throughput

0.508

High

280718

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.508

High

451211

NFL
Neurofilament light polypeptide

1

8

High-throughput

0.508

High

474819

VIME
Vimentin

1

7

High-throughput

0.508

High

552635

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.508

High

555507

SKIL
Ski-like protein

1

2

High-throughput

0.508

High

1088445

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.508

High

1324584

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.508

High

1324587

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.508

High

1324594

MAGH1
Melanoma-associated antigen H1

1

2

High-throughput

0.508

High

1324612

ZHX1
Zinc fingers and homeoboxes protein 1

1

2

High-throughput

0.508

High

698217

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

Small-scale

0.501

High

799292

BRCA1
Breast cancer type 1 susceptibility protein

1

11

Small-scale

0.501

High

833992

HNF4A
Hepatocyte nuclear factor 4-alpha

1

13

Small-scale

0.501

High

887443

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.501

High

1064387

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

1

Small-scale

0.501

High

1093382

TRI32
E3 ubiquitin-protein ligase TRIM32

1

12

Small-scale

0.501

High

1109891

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.501

High

1129647

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

Small-scale

0.501

High

1231614

PLAG1
Zinc finger protein PLAG1

1

6

Small-scale

0.501

High

1324575

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.501

High

425196

IPSP
Plasma serine protease inhibitor

1

1

High-throughput

0.494

High

137337

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.493

High

230062

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.493

High

251461

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

0

High-throughput

0.493

High

261011

SHOX2
Short stature homeobox protein 2

1

0

High-throughput

0.493

High

282274

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

422566

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

556206

CADH1
Cadherin-1

1

0

High-throughput

0.493

High

697950

CALR
Calreticulin

1

0

High-throughput

0.493

High

788097

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

943272

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.493

High

1009801

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.493

High

1131013

LPIN1
Phosphatidate phosphatase LPIN1

1

0

High-throughput

0.493

High

1142247

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

1292072

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.493

High

1307690

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.493

High

1324572

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.493

High

1324582

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.493

High

1324583

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.493

High

1324598

MYOZ1
Myozenin-1

1

0

High-throughput

0.493

High

1324603

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.493

High

1324611

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.493

High

1324617

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.493

High

213624

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.489

High

1307136

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.488

High

332165

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.486

High

889458

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.486

High

1134277

IMB1
Importin subunit beta-1

1

0

High-throughput

0.486

High

1212418

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.486

High

1324595

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

High-throughput

0.486

High

173722

BTAF1
TATA-binding protein-associated factor 172

1

6

High-throughput

0.481

High

436942

K1C18
Keratin, type I cytoskeletal 18

1

3

High-throughput

0.481

High

555717

ACTN1
Alpha-actinin-1

1

3

High-throughput

0.481

High

589143

RFA2
Replication protein A 32 kDa subunit

1

4

Small-scale

0.481

High

731460

STIP1
Stress-induced-phosphoprotein 1

1

5

Small-scale

0.481

High

1217972

MYOME
Myomegalin

1

4

High-throughput

0.481

High

1324564

SERB1
SERPINE1 mRNA-binding protein 1

1

3

Small-scale

0.481

High

1324579

OPTN
Optineurin

1

6

High-throughput

0.481

High

1324590

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.481

High

143116

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

162627

ANM5
Protein arginine N-methyltransferase 5

1

2

Small-scale

0.479

High

210052

CRX
Cone-rod homeobox protein

1

4

High-throughput

0.479

High

342956

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

Small-scale

0.479

High

372558

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

385960

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

474122

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

502054

H2AZ
Histone H2A.Z

1

3

High-throughput

0.479

High

834206

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.479

High

883608

CENPA
Histone H3-like centromeric protein A

1

11

High-throughput

0.479

High

980923

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

998536

H31
Histone H3.1

1

11

High-throughput

0.479

High

1004819

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1017018

H33
Histone H3.3

1

11

High-throughput

0.479

High

1054743

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

1087866

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1097416

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1133531

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1145749

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

1

Small-scale

0.479

High

1161324

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

1217154

RIF1
Telomere-associated protein RIF1

1

4

Small-scale

0.479

High

1324592

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1324601

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.479

High

1324605

ZMYM2
Zinc finger MYM-type protein 2

1

4

High-throughput

0.479

High

1324606

REV1
DNA repair protein REV1

1

3

Small-scale

0.479

High

1324607

KDM5B
Lysine-specific demethylase 5B

1

2

Small-scale

0.479

High

1324614

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

391637

FRIH
Ferritin heavy chain

1

0

High-throughput

0.460

High

402635

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.460

High

929326

OAZ1
Ornithine decarboxylase antizyme 1

1

0

High-throughput

0.460

High

1324588

SH3G3
Endophilin-A3

1

0

High-throughput

0.460

High

1324609

PHF11
PHD finger protein 11

1

0

High-throughput

0.460

High

129252

MEN1
Menin

1

0

Small-scale

0.458

High

187534

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

642573

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.458

High

697175

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

1040849

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

Small-scale

0.458

High

1238439

ZN746
Zinc finger protein 746

1

0

Small-scale

0.458

High

1324593

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1324568

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.457

High

530072

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

209610

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.439

High

1250733

MPRIP
Myosin phosphatase Rho-interacting protein

1

4

High-throughput

0.439

High

1099842

I15RA
Interleukin-15 receptor subunit alpha

1

0

High-throughput

0.282

High

1155365

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.279

Low

1324580

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.279

Low

1324581

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

1324602

TM160
Transmembrane protein 160

1

0

High-throughput

0.279

Low

1324615

HBS1L
HBS1-like protein

1

0

High-throughput

0.279

Low

99211

F2Z2M7
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.268

Low

1240802

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

1324573

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

1324589

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.268

Low

636745

PTN
Pleiotrophin

1

0

High-throughput

0.265

Low

1164462

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.265

Low

562215

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025