Protein: LSM4
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)

Gene: LSM4
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q9Y4Z0

Gene Ontology (top 5):
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356296

LSM7
U6 snRNA-associated Sm-like protein LSm7

8

20

Small-scale

0.970

High

167728

LSM1
U6 snRNA-associated Sm-like protein LSm1

6

20

Small-scale

0.940

High

1063317

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

5

20

High-throughput

0.925

High

912260

LSM6
U6 snRNA-associated Sm-like protein LSm6

5

19

Small-scale

0.922

High

321444

LSM8
U6 snRNA-associated Sm-like protein LSm8

5

20

Small-scale

0.920

High

202556

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

4

8

High-throughput

0.895

High

912211

LSM3
U6 snRNA-associated Sm-like protein LSm3

4

20

Small-scale

0.886

High

1377523

LSM2
U6 snRNA-associated Sm-like protein LSm2

4

16

Small-scale

0.886

High

1198423

PATL1
Protein PAT1 homolog 1

4

6

Small-scale

0.881

High

912602

SMD2
Small nuclear ribonucleoprotein Sm D2

3

20

High-throughput

0.861

High

928049

RSMN
Small nuclear ribonucleoprotein-associated protein N

3

18

High-throughput

0.861

High

1377916

LSM5
U6 snRNA-associated Sm-like protein LSm5

3

20

High-throughput

0.861

High

911779

RUXE
Small nuclear ribonucleoprotein E

3

12

High-throughput

0.858

High

867495

ICLN
Methylosome subunit pICln

2

10

High-throughput

0.811

High

912008

RUXF
Small nuclear ribonucleoprotein F

2

20

High-throughput

0.789

High

442631

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

14

High-throughput

0.754

High

1064898

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

12

High-throughput

0.754

High

197113

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

5

20

High-throughput

0.716

High

269283

WBP4
WW domain-binding protein 4

1

6

High-throughput

0.691

High

448868

RU1C
U1 small nuclear ribonucleoprotein C

1

6

High-throughput

0.691

High

539204

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

16

High-throughput

0.691

High

912765

SMD3
Small nuclear ribonucleoprotein Sm D3

1

14

High-throughput

0.691

High

1025615

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

4

0

High-throughput

0.675

High

207854

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

3

1

High-throughput

0.675

High

153838

ANM5
Protein arginine N-methyltransferase 5

3

4

Small-scale

0.656

High

1184414

MEPCE
7SK snRNA methylphosphate capping enzyme

3

5

High-throughput

0.656

High

912405

SMD1
Small nuclear ribonucleoprotein Sm D1

1

14

High-throughput

0.618

High

1159359

PRP8
Pre-mRNA-processing-splicing factor 8

1

8

High-throughput

0.618

High

300299

PRP6
Pre-mRNA-processing factor 6

2

17

High-throughput

0.611

High

446855

SNRPA
U1 small nuclear ribonucleoprotein A

2

19

High-throughput

0.611

High

1037927

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

4

High-throughput

0.611

High

1309327

MEP50
Methylosome protein WDR77

2

16

High-throughput

0.611

High

1377719

RBGP1
Rab GTPase-activating protein 1

2

3

High-throughput

0.611

High

508789

TOP1
DNA topoisomerase 1

2

3

Small-scale

0.602

High

1377847

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

4

Small-scale

0.601

High

81776

RBG10
Rab GTPase-activating protein 1-like, isoform 10

3

1

Small-scale

0.599

High

1084949

SMN
Survival motor neuron protein

2

7

Small-scale

0.595

High

203566

PPIH
Peptidyl-prolyl cis-trans isomerase H

2

4

High-throughput

0.584

High

1288409

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

14

High-throughput

0.584

High

1285002

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

87377

PATL2
Protein PAT1 homolog 2

1

5

Small-scale

0.575

High

1033767

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.573

High

1357457

RHG26
Rho GTPase-activating protein 26

2

1

High-throughput

0.571

High

242952

GAS7
Growth arrest-specific protein 7

2

1

High-throughput

0.553

High

1288604

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

High-throughput

0.549

High

1295457

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

0

High-throughput

0.549

High

199850

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.536

High

257852

SIN3B
Paired amphipathic helix protein Sin3b

1

1

High-throughput

0.536

High

268913

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.536

High

441398

RU2B
U2 small nuclear ribonucleoprotein B''

1

15

High-throughput

0.536

High

451623

CLCA
Clathrin light chain A

1

3

High-throughput

0.536

High

451761

CLCB
Clathrin light chain B

1

3

High-throughput

0.536

High

727115

FUS
RNA-binding protein FUS

1

16

High-throughput

0.536

High

996979

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1054708

RBM39
RNA-binding protein 39

1

10

High-throughput

0.536

High

1062808

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1073755

SF3A2
Splicing factor 3A subunit 2

1

7

High-throughput

0.536

High

1074279

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

1084679

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

1199121

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

4

High-throughput

0.536

High

1263065

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

9

High-throughput

0.536

High

1288080

TMCO6
Transmembrane and coiled-coil domain-containing protein 6

1

1

High-throughput

0.536

High

1310572

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.536

High

1312113

RBM42
RNA-binding protein 42

1

13

High-throughput

0.536

High

1332268

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

2

High-throughput

0.536

High

1336068

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

4

High-throughput

0.536

High

1343245

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

1

High-throughput

0.536

High

1377854

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

4

High-throughput

0.536

High

173325

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.518

High

1024452

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.515

High

1239405

ZN511
Zinc finger protein 511

1

0

High-throughput

0.513

High

1103034

SMU1
WD40 repeat-containing protein SMU1

1

12

High-throughput

0.508

High

1292546

TOE1
Target of EGR1 protein 1

1

2

High-throughput

0.508

High

476631

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

1030701

NMI
N-myc-interactor

1

0

High-throughput

0.486

High

1309875

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.486

High

1224451

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.481

High

1334866

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.481

High

149466

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

154884

TCRG1
Transcription elongation regulator 1

1

5

High-throughput

0.479

High

163521

XPO1
Exportin-1

1

6

High-throughput

0.479

High

241919

PQBP1
Polyglutamine-binding protein 1

1

1

High-throughput

0.479

High

245133

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

272319

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

High-throughput

0.479

High

295458

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

303564

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

348350

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

380069

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

450967

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

502717

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

640677

DDX6
Probable ATP-dependent RNA helicase DDX6

1

10

Small-scale

0.479

High

652714

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

721880

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

742633

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

750559

COIL
Coilin

1

2

High-throughput

0.479

High

780388

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

818656

SOX2
Transcription factor SOX-2

1

7

Small-scale

0.479

High

856138

RBM5
RNA-binding protein 5

1

6

High-throughput

0.479

High

903646

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

918204

H4
Histone H4

1

4

High-throughput

0.479

High

918793

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1019190

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1039970

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

1083442

RBBP7
Histone-binding protein RBBP7

1

6

Small-scale

0.479

High

1116658

LARP7
La-related protein 7

1

11

High-throughput

0.479

High

1121222

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

3

High-throughput

0.479

High

1127739

PRC2B
Protein PRRC2B

1

5

High-throughput

0.479

High

1159037

EDC4
Enhancer of mRNA-decapping protein 4

1

1

Small-scale

0.479

High

1201219

THOC4
THO complex subunit 4

1

6

High-throughput

0.479

High

1201806

ZCH18
Zinc finger CCCH domain-containing protein 18

1

9

High-throughput

0.479

High

1232147

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

1234280

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

7

Small-scale

0.479

High

1242171

LS14A
Protein LSM14 homolog A

1

6

Small-scale

0.479

High

1263379

GEMI6
Gem-associated protein 6

1

4

High-throughput

0.479

High

1264221

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1270026

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1270105

PRCC
Proline-rich protein PRCC

1

1

High-throughput

0.479

High

1294285

FUBP3
Far upstream element-binding protein 3

1

1

High-throughput

0.479

High

1313233

DDX23
Probable ATP-dependent RNA helicase DDX23

1

12

High-throughput

0.479

High

1319165

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1333838

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

1347581

GEMI8
Gem-associated protein 8

1

3

High-throughput

0.479

High

1349054

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1349688

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

1354996

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1355475

DDX20
Probable ATP-dependent RNA helicase DDX20

1

13

High-throughput

0.479

High

1357229

FZR1
Fizzy-related protein homolog

1

14

High-throughput

0.479

High

1357599

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

1357697

PHF8
Histone lysine demethylase PHF8

1

1

High-throughput

0.479

High

1377166

FBW1A
F-box/WD repeat-containing protein 1A

1

14

High-throughput

0.479

High

1377448

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.479

High

1377645

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

6

High-throughput

0.479

High

1220227

HOMEZ
Homeobox and leucine zipper protein Homez

1

0

High-throughput

0.460

High

158873

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

329019

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

565076

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

877980

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

922949

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

1131436

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.458

High

1161856

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1333029

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1344424

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1345763

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

3545

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.445

High

497880

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

1047346

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

1129947

RBG1L
Rab GTPase-activating protein 1-like

1

2

High-throughput

0.445

High

1318914

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

211316

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

5

High-throughput

0.407

High

1300522

SIM14
Small integral membrane protein 14

1

0

High-throughput

0.265

Low

495775

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024