HitPredict

Interactor 1: BCL9 (O00512)
B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)
Gene: BCL9

Interactor 2: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006366 - transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1426 Hs			1 349
+	Hs
		131737 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35
+	Hs
		131704 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Hs
		131702 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35
+	Hs
		131711 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		131749 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX3_HUMAN (4-341): 2.69e-14: 75.4: 13.37
+	Hs
		131736 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX4_HUMAN (4-73): 8.65e-14: 73.9: 26.76
+	Hs
		131726 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX8_HUMAN (5-77): 1.09e-09: 61.1: 21.92
+	Hs
		131751 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		LHX6_HUMAN (5-74): 2.11e-09: 60.4: 22.86
+	Hs
		899924 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		ISL1_HUMAN (1-349): 1.96e-89: 274: 100.00
+	Hs
		1200126 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		ISL2_HUMAN (1-349): 3.08e-80: 250: 73.35
+	Hs
		839836 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Hs
		822688 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35
+	Hs
		839774 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Hs
		839785 KMT2C_HUMAN (40-881): 1.95e-11: 71.6: 8.19		LHX2_HUMAN (3-316): 1.86e-58: 195: 25.55
+	Hs
		822650 KMT2C_HUMAN (40-881): 1.95e-11: 71.6: 8.19		LHX1_HUMAN (16-349): 3.6e-57: 192: 27.35
+	Hs
		903746 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LMO4_HUMAN (17-132): 4e-25: 101: 40.34
+	Hs
		1350240 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX3_HUMAN (4-341): 2.69e-14: 75.4: 13.37
+	Hs
		1281194 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		LHX4_HUMAN (4-73): 8.65e-14: 73.9: 26.76
+	Hs
		1200125 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX4_HUMAN (4-73): 8.65e-14: 73.9: 26.76
+	Hs
		1200133 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		LHX6_HUMAN (5-74): 2.11e-09: 60.4: 22.86