HitPredict

Interactor 1: BCL9 (O00512)
B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)
Gene: BCL9

Interactor 2: PYGO1 (Q9Y3Y4)
Pygopus homolog 1
Gene: PYGO1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.705

Property	Details
Experiments	31073027, 14612447, 24981860, 18498752
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, tandem affinity purification, molecular sieving
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1426 Hs			1 419
+	Hs
		131740 BCL9_HUMAN (1-1426): 4.24e-149: 492: 100.00		PYGO2_HUMAN (2-419): 4.18e-47: 168: 32.38
+	Hs
		1200134 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Hs
		1200128 BCL9L_HUMAN (4-1218): 2.15e-17: 91: 11.06		PYGO2_HUMAN (2-419): 4.18e-47: 168: 32.38
+	Hs
		554259 MUC1_HUMAN (2-890): 1.27e-49: 195: 10.51		MUC1_HUMAN (72-355): 4.45e-10: 63.9: 7.39
+	Hs
		146292 ARI1A_HUMAN (390-1315): 8.07e-10: 65.9: 10.37		CHD7_HUMAN (20-302): 2.74e-38: 149: 10.71
+	Mm
		1351630 PCLO_MOUSE (4-1064): 5.53e-27: 122: 8.26		PCLO_MOUSE (90-355): 1.22e-12: 72.4: 8.27
+	Hs
		1057773 NCOA6_HUMAN (1-1013): 5.94e-12: 72.9: 7.69		KMT2C_HUMAN (38-338): 3.64e-25: 110: 11.68
+	Hs
		124109 CHD7_HUMAN (439-953): 5.16e-20: 99.7: 12.01		SPT5H_HUMAN (8-212): 2.96e-14: 77: 12.80
+	Mm
		57185 CHD7_MOUSE (631-1207): 1.64e-09: 65: 11.32		SMCA4_MOUSE (21-312): 1.3e-20: 96.6: 12.16
+	Mm
		57767 ARI1A_MOUSE (651-1424): 4.17e-09: 63.6: 9.82		SMCA4_MOUSE (21-312): 1.3e-20: 96.6: 12.16
+	Hs
		124057 MINT_HUMAN (2-1423): 1.23e-12: 75.6: 7.47		SPT5H_HUMAN (8-212): 2.96e-14: 77: 12.80
+	Hs
		124137 NCOR2_HUMAN (2-1293): 5.66e-11: 69.8: 7.88		SPT5H_HUMAN (8-212): 2.96e-14: 77: 12.80
+	Hs
		123779 ARI1A_HUMAN (390-1315): 8.07e-10: 65.9: 10.37		SPT5H_HUMAN (8-212): 2.96e-14: 77: 12.80
+	Dm
		113976 M9PB30_DROME (1-451): 1.1e-12: 75.6: 10.72		M9PB30_DROME (64-357): 7.92e-09: 60: 9.43
+	Dm
		375663 Q9VLS7_DROME (705-1418): 5.04e-11: 70.2: 11.20		RPB1_DROME (77-352): 1.22e-09: 62.7: 14.52
+	Mm
		1207212 NCOA6_MOUSE (562-1420): 1.18e-11: 72.1: 8.27		KMT2C_MOUSE (8-354): 7.98e-09: 60: 10.99
+	Mm
		57179 ARI1A_MOUSE (651-1424): 4.17e-09: 63.6: 9.82		CHD7_MOUSE (10-354): 6.52e-10: 63.5: 10.89