HitPredict

Interactor 1: MLP3B (Q9GZQ8)
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)
Gene: MAP1LC3B

Interactor 2: ATG4B (Q9Y4P1)
Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B)
Gene: ATG4B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 15355958, 28287329, 16169070, 32296183, 31006538, 20562859, 21900206, 20010802, 24023838, 19549685, 19322194, 18083104, unassigned1304
Identification Methods enzymatic study, pull down, two hybrid, affinity chromatography technology, protease assay, x-ray crystallography, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid and 2 others

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Interaction Type direct interaction, physical association, protein cleavage, cleavage reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ATG8~Peptidase_C54
Common GO terms GO:0000045 - autophagosome assembly
GO:0000421 - autophagosome membrane
GO:0000423 - mitophagy
GO:0005739 - mitochondrion
GO:0005829 - cytosol
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 125
Hs

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Last updated: 15 Jul 2024