Protein: EI2BE
Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)

Gene: EI2BE, EIF2B5
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q13144

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1095879

EI2BA
Translation initiation factor eIF2B subunit alpha

5

19

Small-scale

0.716

High

890114

EI2BB
Translation initiation factor eIF2B subunit beta

4

19

Small-scale

0.696

High

1095940

OPN3
Opsin-3

3

5

High-throughput

0.667

High

1095953

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

2

High-throughput

0.667

High

639126

SYT1
Synaptotagmin-1

3

3

High-throughput

0.662

High

1095958

FZD10
Frizzled-10

3

1

High-throughput

0.662

High

1095955

EI2BD
Translation initiation factor eIF2B subunit delta

3

16

Small-scale

0.660

High

1095910

UXS1
UDP-glucuronic acid decarboxylase 1

2

1

High-throughput

0.628

High

1095949

EI2BG
Translation initiation factor eIF2B subunit gamma

2

17

Small-scale

0.619

High

832027

IF2G
Eukaryotic translation initiation factor 2 subunit 3

2

11

High-throughput

0.611

High

733492

GP183
G-protein coupled receptor 183

3

12

High-throughput

0.609

High

845422

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

8

High-throughput

0.609

High

1095902

STX12
Syntaxin-12

3

2

High-throughput

0.609

High

1095935

P2RX4
P2X purinoceptor 4

3

2

High-throughput

0.609

High

1095959

CAH14
Carbonic anhydrase 14

3

1

High-throughput

0.609

High

286649

STX11
Syntaxin-11

3

3

High-throughput

0.607

High

1095908

SIGL1
SIGLEC family-like protein 1

3

2

High-throughput

0.604

High

1095943

PACC1
Proton-activated chloride channel

3

3

High-throughput

0.604

High

1022846

EFNB1
Ephrin-B1

2

6

High-throughput

0.601

High

1095920

IGSF8
Immunoglobulin superfamily member 8

3

2

High-throughput

0.593

High

891506

GSK3B
Glycogen synthase kinase-3 beta

2

5

Small-scale

0.585

High

241562

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

363212

EGFR
Epidermal growth factor receptor

2

4

High-throughput

0.584

High

50545

HACL2
2-hydroxyacyl-CoA lyase 2

2

5

High-throughput

0.574

High

438074

GLPB
Glycophorin-B

2

5

High-throughput

0.574

High

640159

EPHA1
Ephrin type-A receptor 1

2

2

High-throughput

0.574

High

592719

LEUK
Leukosialin

2

1

High-throughput

0.558

High

760752

CD68
Macrosialin

2

1

High-throughput

0.558

High

1095900

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

3

High-throughput

0.558

High

1095882

CD226
CD226 antigen

2

4

High-throughput

0.549

High

1095904

TM192
Transmembrane protein 192

2

1

High-throughput

0.549

High

1095909

SYT2
Synaptotagmin-2

2

3

High-throughput

0.549

High

194824

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

4

High-throughput

0.536

High

220161

TNF14
Tumor necrosis factor ligand superfamily member 14

1

1

High-throughput

0.536

High

330927

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.536

High

351892

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.536

High

407081

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.536

High

444968

S10A9
Protein S100-A9

1

1

High-throughput

0.536

High

457860

INVO
Involucrin

1

2

High-throughput

0.536

High

486556

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

923588

TTC3
E3 ubiquitin-protein ligase TTC3

1

7

High-throughput

0.536

High

969826

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1013289

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

1065690

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.536

High

1095875

MYO9B
Unconventional myosin-IXb

1

4

High-throughput

0.536

High

1095883

MA7D1
MAP7 domain-containing protein 1

1

2

High-throughput

0.536

High

1095885

CEP78
Centrosomal protein of 78 kDa

1

1

High-throughput

0.536

High

1095891

S27A4
Long-chain fatty acid transport protein 4

1

8

High-throughput

0.536

High

1095894

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.536

High

1095905

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.536

High

1095918

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.536

High

1095925

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

16

High-throughput

0.536

High

1095928

F210A
Protein FAM210A

1

1

High-throughput

0.536

High

1095930

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

2

High-throughput

0.536

High

1095938

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.536

High

1095946

INCE
Inner centromere protein

1

1

High-throughput

0.536

High

1095947

MYO5C
Unconventional myosin-Vc

1

3

High-throughput

0.536

High

1095948

ASH1L
Histone-lysine N-methyltransferase ASH1L

1

1

High-throughput

0.536

High

1095963

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

1095964

EXOG
Nuclease EXOG, mitochondrial

1

2

High-throughput

0.536

High

1095965

MYO5A
Unconventional myosin-Va

1

3

High-throughput

0.536

High

1095967

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

17

High-throughput

0.536

High

914412

EFNB2
Ephrin-B2

2

6

High-throughput

0.521

High

830661

CCNF
Cyclin-F

1

5

High-throughput

0.515

High

1095878

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.515

High

1095916

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

510040

ZN865
Zinc finger protein 865

1

0

High-throughput

0.513

High

868681

LEG7
Galectin-7

1

0

High-throughput

0.513

High

948194

ZN445
Zinc finger protein 445

1

0

High-throughput

0.513

High

1095880

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1095892

LTMD1
LETM1 domain-containing protein 1

1

0

High-throughput

0.513

High

1095896

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.513

High

1095962

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.513

High

221850

CHM2A
Charged multivesicular body protein 2a

1

2

High-throughput

0.508

High

1095877

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

Small-scale

0.501

High

1095915

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

6

Small-scale

0.501

High

136496

GOLI4
Golgi integral membrane protein 4

1

3

High-throughput

0.489

High

165937

FFAR1
Free fatty acid receptor 1

1

14

High-throughput

0.489

High

253558

PEX10
Peroxisome biogenesis factor 10

1

1

High-throughput

0.489

High

253835

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

337723

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.489

High

669268

PTAFR
Platelet-activating factor receptor

1

11

High-throughput

0.489

High

683235

TNR5
Tumor necrosis factor receptor superfamily member 5

1

1

High-throughput

0.489

High

711553

NK3R
Neuromedin-K receptor

1

5

High-throughput

0.489

High

749198

CD70
CD70 antigen

1

1

High-throughput

0.489

High

762402

BTC
Probetacellulin [Cleaved into: Betacellulin

1

2

High-throughput

0.489

High

1095873

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

14

High-throughput

0.489

High

1095874

PLD1
Phospholipase D1

1

1

High-throughput

0.489

High

1095881

P2RY6
P2Y purinoceptor 6

1

12

High-throughput

0.489

High

1095887

ATD3B
ATPase family AAA domain-containing protein 3B

1

6

High-throughput

0.489

High

1095889

PHLB3
Pleckstrin homology-like domain family B member 3

1

2

High-throughput

0.489

High

1095898

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

1095901

CHSS1
Chondroitin sulfate synthase 1

1

1

High-throughput

0.489

High

1095907

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

3

High-throughput

0.489

High

1095914

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.489

High

1095923

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

1

High-throughput

0.489

High

1095926

F210B
Protein FAM210B, mitochondrial

1

1

High-throughput

0.489

High

1095927

B3GT6
Beta-1,3-galactosyltransferase 6

1

1

High-throughput

0.489

High

1095929

NECT4
Nectin-4

1

3

High-throughput

0.489

High

1095932

MA7D2
MAP7 domain-containing protein 2

1

5

High-throughput

0.489

High

1095934

SEC62
Translocation protein SEC62

1

1

High-throughput

0.489

High

1095939

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.489

High

1095944

PCDH9
Protocadherin-9

1

1

High-throughput

0.489

High

1095950

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

2

High-throughput

0.489

High

1095952

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

1095956

CC018
Uncharacterized protein C3orf18

1

2

High-throughput

0.489

High

1095966

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.489

High

1095968

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

422030

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

129038

MEN1
Menin

1

1

High-throughput

0.479

High

172761

XPO1
Exportin-1

1

9

High-throughput

0.479

High

345745

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

371918

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

588590

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

627643

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

8

High-throughput

0.479

High

695346

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

934062

XPO2
Exportin-2

1

9

High-throughput

0.479

High

942592

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.479

High

964907

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

1095876

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1095888

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1095895

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1095897

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1095906

PNKD
Probable thioesterase PNKD

1

2

High-throughput

0.479

High

1095919

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1095921

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1095924

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1095942

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1095951

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

1095954

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1095922

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

171448

S27A2
Long-chain fatty acid transport protein 2

1

8

High-throughput

0.445

High

429814

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

529726

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

532171

CD28
T-cell-specific surface glycoprotein CD28

1

1

High-throughput

0.445

High

722867

SSR2
Somatostatin receptor type 2

1

9

High-throughput

0.445

High

1095886

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1095931

CK5P2
CDK5 regulatory subunit-associated protein 2

1

3

High-throughput

0.445

High

411848

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

768084

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1095893

LMBRL
Protein LMBR1L

1

5

High-throughput

0.437

High

1095903

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

1095941

EMRE
Essential MCU regulator, mitochondrial

1

2

High-throughput

0.437

High

1095957

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

104142

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

1095899

SO6A1
Solute carrier organic anion transporter family member 6A1

1

3

High-throughput

0.407

High

932338

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1095890

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.279

Low

1095912

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1095913

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1095917

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.279

Low

1095933

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.279

Low

1095936

MICU1
Calcium uptake protein 1, mitochondrial

1

0

High-throughput

0.279

Low

1095937

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.279

Low

1095945

JPH1
Junctophilin-1

1

0

High-throughput

0.279

Low

1095960

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low

1095961

STX8
Syntaxin-8

1

0

High-throughput

0.279

Low

105856

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1095911

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1095884

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025