Protein: PNKD
Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)

Gene: PNKD
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q8N490

Gene Ontology (top 5):
GO:0004416 - hydroxyacylglutathione hydrolase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

848900

MAGAB
Melanoma-associated antigen 11

4

1

High-throughput

0.700

High

1326206

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

4

High-throughput

0.667

High

873407

LSS
Lanosterol synthase

3

0

High-throughput

0.638

High

1241643

ANM9
Protein arginine N-methyltransferase 9

3

0

High-throughput

0.638

High

251236

RNBP6
Ran-binding protein 6

2

2

High-throughput

0.611

High

334838

IPO7
Importin-7

2

5

High-throughput

0.611

High

1137239

CND1
Condensin complex subunit 1

2

1

High-throughput

0.611

High

1140555

KIF14
Kinesin-like protein KIF14

2

1

High-throughput

0.611

High

1292163

LIPB1
Liprin-beta-1

2

2

High-throughput

0.611

High

1325360

STAG2
Cohesin subunit SA-2

2

1

High-throughput

0.611

High

1326196

CIP2A
Protein CIP2A

2

4

High-throughput

0.611

High

1326198

STAG1
Cohesin subunit SA-1

2

1

High-throughput

0.611

High

1326214

IPO9
Importin-9

2

5

High-throughput

0.611

High

1326224

GLP3L
Golgi phosphoprotein 3-like

2

2

High-throughput

0.611

High

1326225

GOLP3
Golgi phosphoprotein 3

2

2

High-throughput

0.611

High

1326242

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

1

High-throughput

0.611

High

1326244

DICER
Endoribonuclease Dicer

2

1

High-throughput

0.611

High

422574

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

167102

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.585

High

284336

GEMI
Geminin

2

0

High-throughput

0.585

High

351138

ECD
Protein ecdysoneless homolog

2

0

High-throughput

0.585

High

828404

PEX19
Peroxisomal biogenesis factor 19

2

0

High-throughput

0.585

High

890855

TSC2
Tuberin

2

0

High-throughput

0.585

High

940153

RRP1
Ribosomal RNA processing protein 1 homolog A

2

0

High-throughput

0.585

High

1083276

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.585

High

1108800

ASAH1
Acid ceramidase

2

0

High-throughput

0.585

High

1120029

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

0

High-throughput

0.585

High

1150665

TRBP2
RISC-loading complex subunit TARBP2

2

0

High-throughput

0.585

High

1157587

TAF12
Transcription initiation factor TFIID subunit 12

2

0

High-throughput

0.585

High

1187976

GON4L
GON-4-like protein

2

0

High-throughput

0.585

High

1229175

INT3
Integrator complex subunit 3

2

0

High-throughput

0.585

High

1273955

DYM
Dymeclin

2

0

High-throughput

0.585

High

1275938

SETX
Probable helicase senataxin

2

0

High-throughput

0.585

High

1295252

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

2

0

High-throughput

0.585

High

1326190

AL14E
ARL14 effector protein

2

0

High-throughput

0.585

High

1326191

MIGA1
Mitoguardin 1

2

0

High-throughput

0.585

High

1326199

ATRIP
ATR-interacting protein

2

0

High-throughput

0.585

High

1326202

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

0

High-throughput

0.585

High

1326208

KBP
KIF-binding protein

2

0

High-throughput

0.585

High

1326210

SAAL1
Protein SAAL1

2

0

High-throughput

0.585

High

1326216

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.585

High

1326217

DCNL5
DCN1-like protein 5

2

0

High-throughput

0.585

High

1326219

NUP85
Nuclear pore complex protein Nup85

2

0

High-throughput

0.585

High

1326222

XPO4
Exportin-4

2

0

High-throughput

0.585

High

1326230

MLXIP
MLX-interacting protein

2

0

High-throughput

0.585

High

1326232

SOSSC
SOSS complex subunit C

2

0

High-throughput

0.585

High

1326233

DIAP3
Protein diaphanous homolog 3

2

0

High-throughput

0.585

High

1326237

ARMX3
Armadillo repeat-containing X-linked protein 3

2

0

High-throughput

0.585

High

1326243

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.585

High

164605

TNPO2
Transportin-2

2

4

High-throughput

0.584

High

691793

MK03
Mitogen-activated protein kinase 3

2

0

Small-scale

0.576

High

396500

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

189220

IPO8
Importin-8

2

5

High-throughput

0.558

High

1216515

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

2

1

High-throughput

0.558

High

1326207

HOOK2
Protein Hook homolog 2

2

5

High-throughput

0.558

High

1326238

EI2BD
Translation initiation factor eIF2B subunit delta

2

1

High-throughput

0.558

High

1326239

IPO11
Importin-11

2

5

High-throughput

0.558

High

774089

ADDA
Alpha-adducin

1

1

High-throughput

0.536

High

774159

ADDB
Beta-adducin

1

1

High-throughput

0.536

High

1148265

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

2

High-throughput

0.536

High

1197219

GREB1
Protein GREB1

1

1

High-throughput

0.536

High

1199586

KLH22
Kelch-like protein 22

1

1

High-throughput

0.536

High

1326204

TBCD5
TBC1 domain family member 5

1

1

High-throughput

0.536

High

1326221

GRB1L
GREB1-like protein

1

1

High-throughput

0.536

High

260910

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

841828

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

873369

AL3B2
Aldehyde dehydrogenase family 3 member B2

1

0

High-throughput

0.513

High

967264

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.513

High

1104440

ILK
Scaffold protein ILK

1

0

High-throughput

0.513

High

1118522

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.513

High

1120471

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1254255

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.513

High

1326203

NICA
Nicastrin

1

0

High-throughput

0.513

High

1326240

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

1326248

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

1

0

High-throughput

0.513

High

508274

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

541109

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

656184

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.493

High

167322

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

1096460

PAK1
Serine/threonine-protein kinase PAK 1

1

0

High-throughput

0.493

High

72931

ESPN
Espin

1

1

High-throughput

0.489

High

273689

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.479

High

690298

STOM
Stomatin

1

1

High-throughput

0.479

High

766688

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

841216

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.479

High

1035772

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1095906

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.479

High

1161148

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

1326205

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1326227

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1326229

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1326236

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

109330

G5E962
MAGE family member A11

1

1

High-throughput

0.470

High

1326218

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.470

High

1326245

KLH20
Kelch-like protein 20

1

0

Small-scale

0.460

High

124620

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.458

High

178329

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

789925

FDFT
Squalene synthase

1

0

High-throughput

0.458

High

831059

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

945272

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.458

High

1233762

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.458

High

1326192

NUP37
Nucleoporin Nup37

1

0

High-throughput

0.458

High

1326220

RTF2
Replication termination factor 2

1

0

High-throughput

0.458

High

1326228

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

722532

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.445

High

943990

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1139498

S39AE
Metal cation symporter ZIP14

1

4

High-throughput

0.445

High

1195633

Q4LE60
TNPO2 variant protein

1

4

High-throughput

0.445

High

1197827

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.445

High

1242860

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.445

High

1326200

CTR3
Cationic amino acid transporter 3

1

1

High-throughput

0.445

High

1326201

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.445

High

1326223

S39A8
Metal cation symporter ZIP8

1

4

High-throughput

0.445

High

445024

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

890140

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.437

High

1326209

RNF31
E3 ubiquitin-protein ligase RNF31

1

4

High-throughput

0.437

High

1326226

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1326231

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.437

High

391350

FRIL
Ferritin light chain

1

0

High-throughput

0.426

High

869624

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.426

High

1093545

TRDN
Triadin

1

0

High-throughput

0.426

High

1326213

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

1326215

B3A4
Anion exchange protein 4

1

0

High-throughput

0.426

High

1326241

SO3A1
Solute carrier organic anion transporter family member 3A1

1

0

High-throughput

0.426

High

1326246

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.426

High

137251

EXOC5
Exocyst complex component 5

2

0

High-throughput

0.318

High

181641

CETN3
Centrin-3

2

0

High-throughput

0.318

High

216104

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

2

0

High-throughput

0.318

High

295346

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

High-throughput

0.318

High

915996

NUP98
Nuclear pore complex protein Nup98-Nup96

2

0

High-throughput

0.318

High

1208188

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

2

0

High-throughput

0.318

High

1278611

HEAT3
HEAT repeat-containing protein 3

2

0

High-throughput

0.318

High

1325265

VPS8
Vacuolar protein sorting-associated protein 8 homolog

2

0

High-throughput

0.318

High

1326194

FBX30
F-box only protein 30

2

0

High-throughput

0.318

High

1326195

TBC15
TBC1 domain family member 15

2

0

High-throughput

0.318

High

1326197

DCA11
DDB1- and CUL4-associated factor 11

2

0

High-throughput

0.318

High

1326212

RADIL
Ras-associating and dilute domain-containing protein

2

0

High-throughput

0.318

High

1326235

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.318

High

1326247

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

2

0

High-throughput

0.318

High

1271369

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.299

High

320573

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

0

High-throughput

0.298

High

1326211

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.298

High

964673

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.279

Low

1219945

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

0

High-throughput

0.279

Low

1239242

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

173725

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.249

Low

294008

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1085248

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

1326193

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

High-throughput

0.249

Low

1326234

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025