HitPredict

Interactor 1: CBR4 (Q8N4T8)
3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1)
Gene: CBR4

Interactor 2: DHB8 (Q92506)
(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
Gene: HSD17B8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.895

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, unassigned3799
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains adh_short_C2~adh_short_C2
Common GO terms GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006633 - fatty acid biosynthetic process
GO:0048038 - quinone binding
GO:0051290 - protein heterotetramerization
and 1 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 237
Hs

1 261
+ Hs
+ At
+ At
+ At
+ At
+ Ss
+ Ec
+ At
+ At
+ Dm
+ Mm
+ Mm
+ At
+ At
+ At
+ Dm
+ Dm

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Last updated: 11Aug2025