Protein: DHRS4
Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4)

Gene: DHRS4
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9BTZ2

Gene Ontology (top 5):
GO:0000253 - 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
GO:0004090 - carbonyl reductase (NADPH) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005777 - peroxisome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1245786

DR4L2
Dehydrogenase/reductase SDR family member 4-like 2

2

17

High-throughput

0.712

High

297071

DHRS3
Short-chain dehydrogenase/reductase 3

1

17

High-throughput

0.691

High

1409639

DHB14
L-fucose dehydrogenase

1

16

High-throughput

0.691

High

1413842

DHRS6
Dehydrogenase/reductase SDR family member 6

1

16

High-throughput

0.691

High

716615

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

1

High-throughput

0.667

High

888551

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

1

High-throughput

0.662

High

333710

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

3

0

High-throughput

0.638

High

722742

AL1B1
Aldehyde dehydrogenase X, mitochondrial

3

0

High-throughput

0.638

High

1042661

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

1385735

BIRC7
Baculoviral IAP repeat-containing protein 7

3

0

High-throughput

0.638

High

1413844

RM37
Large ribosomal subunit protein mL37

3

0

High-throughput

0.638

High

896298

PEX5
Peroxisomal targeting signal 1 receptor

3

1

Small-scale

0.631

High

681909

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

1413839

DHRS4
Dehydrogenase/reductase SDR family member 4

1

17

High-throughput

0.618

High

908642

PRELP
Prolargin

3

1

High-throughput

0.609

High

449579

HEXA
Beta-hexosaminidase subunit alpha

2

0

High-throughput

0.602

High

635155

CP2B6
Cytochrome P450 2B6

2

0

High-throughput

0.602

High

716726

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.602

High

1413841

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

1413848

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.602

High

275733

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

2

0

High-throughput

0.585

High

1413843

RM13
Large ribosomal subunit protein uL13m

2

0

High-throughput

0.585

High

104697

F6VUV4
Dehydrogenase/reductase 4 like 2

3

10

High-throughput

0.585

High

1384943

TRI43
Tripartite motif-containing protein 43

2

1

High-throughput

0.574

High

471217

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

1413847

GSX1
GS homeobox 1

1

2

High-throughput

0.536

High

425953

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

551668

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.513

High

848711

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

1024442

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.513

High

1235938

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.513

High

1242618

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1357370

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.513

High

1411617

FSP1
Ferroptosis suppressor protein 1

1

0

High-throughput

0.513

High

1413846

CST11
Cystatin-11

1

0

High-throughput

0.513

High

662074

DGKA
Diacylglycerol kinase alpha

1

0

High-throughput

0.493

High

1413855

M2GD
Dimethylglycine dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

1395161

HIPL1
HHIP-like protein 1

1

1

High-throughput

0.489

High

122547

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

2

High-throughput

0.479

High

227657

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

229565

NRDC
Nardilysin

1

4

High-throughput

0.479

High

282062

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

396844

ESR1
Estrogen receptor

1

3

High-throughput

0.479

High

400011

CATA
Catalase

1

1

High-throughput

0.479

High

414529

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

554830

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

1026528

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1083727

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1092635

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.479

High

1162525

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1206241

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

1216279

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

1

High-throughput

0.479

High

1286662

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

2

High-throughput

0.479

High

1313388

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1339527

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

1

High-throughput

0.479

High

1367155

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1383395

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

1

High-throughput

0.479

High

1413853

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

278955

PEX14
Peroxisomal membrane protein PEX14

1

0

Small-scale

0.464

High

50870

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.458

High

283951

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

482536

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

774589

BASI
Basigin

1

0

High-throughput

0.458

High

937883

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

940622

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

1162226

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.458

High

1246961

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.458

High

1394079

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.458

High

1413840

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.458

High

1413845

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.458

High

1413857

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1413858

BOLA1
BolA-like protein 1

1

0

High-throughput

0.458

High

1413859

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

142405

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

591358

CD44
CD44 antigen

1

1

High-throughput

0.445

High

829519

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.445

High

1255318

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1413856

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

935965

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.426

High

616802

SDC1
Syndecan-1

1

4

High-throughput

0.407

High

760495

SDC2
Syndecan-2

1

4

High-throughput

0.407

High

505848

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

0

High-throughput

0.347

High

1162736

QPCT
Glutaminyl-peptide cyclotransferase

3

0

High-throughput

0.347

High

1413854

SUN2
SUN domain-containing protein 2

3

0

High-throughput

0.345

High

1361975

KLHL6
Kelch-like protein 6

2

0

High-throughput

0.328

High

1210430

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

0

High-throughput

0.279

Low

1363219

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1413849

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

1413852

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

1390461

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

0

High-throughput

0.249

Low

1413851

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low

1413850

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025