HitPredict

Interactor 1: MLKL (Q8NB16)
Mixed lineage kinase domain-like protein (hMLKL)
Gene: MLKL

Interactor 2: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 29883609, 30420664, 37085671, 27560715, 31358971, 34999730, 24316671, 22265413, 22265414
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0044877 - protein-containing complex binding
and 4 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 471
Hs

1 518
+ Mm
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ Hs
+ At

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Last updated: 11Aug2025