Protein: MLKL
Mixed lineage kinase domain-like protein (hMLKL)

Gene: MLKL
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q8NB16

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1333002

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

9

18

Small-scale

0.963

High

443441

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.698

High

1051269

KPCZ
Protein kinase C zeta type

1

9

High-throughput

0.691

High

1217416

OBSCN
Obscurin

1

2

High-throughput

0.691

High

1332983

LRCH3
DISP complex protein LRCH3

1

20

High-throughput

0.691

High

461710

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.618

High

1109627

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

17

Small-scale

0.618

High

1332978

MLKL
Mixed lineage kinase domain-like protein

1

18

Small-scale

0.618

High

1332988

DCLK3
Serine/threonine-protein kinase DCLK3

1

8

High-throughput

0.618

High

633744

PSB1
Proteasome subunit beta type-1

2

1

High-throughput

0.606

High

954974

S10AA
Protein S100-A10

2

1

High-throughput

0.606

High

1332985

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.578

High

552642

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.536

High

1132394

CASP8
Caspase-8

1

1

High-throughput

0.536

High

1332999

ZN281
Zinc finger protein 281

1

2

High-throughput

0.536

High

1332994

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.518

High

1332995

APC11
Anaphase-promoting complex subunit 11

1

0

High-throughput

0.518

High

1111113

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1328612

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.513

High

1332981

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

1332992

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

288467

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

4

Small-scale

0.501

High

1332984

THOC3
THO complex subunit 3

1

1

High-throughput

0.494

High

1024282

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

0

High-throughput

0.493

High

340651

STABP
STAM-binding protein

1

0

Small-scale

0.480

High

1332993

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.480

High

174560

TRI66
Tripartite motif-containing protein 66

1

7

High-throughput

0.479

High

180874

TIF1A
Transcription intermediary factor 1-alpha

1

7

High-throughput

0.479

High

260183

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

378139

TNFA
Tumor necrosis factor

1

2

Small-scale

0.479

High

419089

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

659259

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.479

High

674248

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

1090797

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

1101855

SKP2
S-phase kinase-associated protein 2

1

20

Small-scale

0.479

High

1332980

PARD3
Partitioning defective 3 homolog

1

7

High-throughput

0.479

High

1332987

CECR2
Chromatin remodeling regulator CECR2

1

3

High-throughput

0.479

High

1332991

SP110
Sp110 nuclear body protein

1

7

High-throughput

0.479

High

1332997

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

3

High-throughput

0.479

High

1332998

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.479

High

1333001

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

342258

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

1113714

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1138402

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1332986

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1332989

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

1332990

MB12B
Multivesicular body subunit 12B

1

0

Small-scale

0.458

High

1332996

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

1227069

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

887029

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

605473

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.282

High

1332982

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1238351

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.249

Low

1239517

ZNT6
Zinc transporter 6

1

0

High-throughput

0.249

Low

1332979

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.249

Low

1333000

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025