Protein: RIPK1
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)

Gene: RIPK1
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q13546

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005123 - death receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622608

TNR1A
Tumor necrosis factor receptor superfamily member 1A

51

18

Small-scale

0.995

High

1096893

FADD
FAS-associated death domain protein

33

20

Small-scale

0.993

High

1109691

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

25

20

Small-scale

0.992

High

1107395

BIRC2
Baculoviral IAP repeat-containing protein 2

14

20

Small-scale

0.985

High

1106828

BIRC3
Baculoviral IAP repeat-containing protein 3

10

20

Small-scale

0.978

High

1109594

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

9

17

Small-scale

0.974

High

1109600

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

7

2

Small-scale

0.965

High

213926

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

20

Small-scale

0.881

High

177866

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

20

Small-scale

0.873

High

1109655

M3K3
Mitogen-activated protein kinase kinase kinase 3

4

20

Small-scale

0.873

High

167892

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

3

14

Small-scale

0.834

High

163297

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

18

Small-scale

0.827

High

461449

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.827

High

1109654

M3K14
Mitogen-activated protein kinase kinase kinase 14

3

20

Small-scale

0.827

High

1109668

PIDD1
p53-induced death domain-containing protein 1

3

20

Small-scale

0.827

High

1022708

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.785

High

1008661

CRADD
Death domain-containing protein CRADD

2

1

Small-scale

0.778

High

1109598

CASP8
Caspase-8

48

8

Small-scale

0.771

High

378088

TNFA
Tumor necrosis factor

35

8

Small-scale

0.769

High

1109693

NEMO
NF-kappa-B essential modulator

28

20

Small-scale

0.769

High

1090628

TRAF2
TNF receptor-associated factor 2

25

20

Small-scale

0.768

High

191215

TLR3
Toll-like receptor 3

2

20

Small-scale

0.754

High

468344

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.754

High

1051225

KPCZ
Protein kinase C zeta type

2

20

Small-scale

0.754

High

639235

TNAP3
Tumor necrosis factor alpha-induced protein 3

8

4

Small-scale

0.753

High

1109620

TCAM1
TIR domain-containing adapter molecule 1

9

5

Small-scale

0.747

High

997696

CSK21
Casein kinase II subunit alpha

2

19

High-throughput

0.737

High

1109629

CSK23
Casein kinase II subunit alpha 3

2

19

High-throughput

0.737

High

1093809

TRAF1
TNF receptor-associated factor 1

5

20

Small-scale

0.722

High

1107683

SQSTM
Sequestosome-1

5

16

Small-scale

0.720

High

876850

KC1A
Casein kinase I isoform alpha

1

10

Small-scale

0.715

High

193016

CFLAR
CASP8 and FADD-like apoptosis regulator

5

8

Small-scale

0.714

High

1109670

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

5

5

Small-scale

0.702

High

1109692

MRCKB
Serine/threonine-protein kinase MRCK beta

1

14

High-throughput

0.698

High

1109645

OPTN
Optineurin

4

20

Small-scale

0.696

High

1109673

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

4

14

Small-scale

0.687

High

1109619

TAXB1
Tax1-binding protein 1

4

14

Small-scale

0.683

High

1109662

ZBP1
Z-DNA-binding protein 1

4

4

Small-scale

0.674

High

946103

MLF1
Myeloid leukemia factor 1

3

3

High-throughput

0.667

High

1109608

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.665

High

1109680

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

High-throughput

0.665

High

1094891

TRAF3
TNF receptor-associated factor 3

3

20

Small-scale

0.664

High

1109672

RN216
E3 ubiquitin-protein ligase RNF216

3

5

Small-scale

0.661

High

675020

TNR6
Tumor necrosis factor receptor superfamily member 6

1

18

Small-scale

0.656

High

1109595

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

Small-scale

0.647

High

1109675

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.647

High

1109690

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.646

High

507933

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

10

Small-scale

0.640

High

288408

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

10

Small-scale

0.634

High

1109649

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

2

6

Small-scale

0.634

High

1109642

NTAN1
Protein N-terminal asparagine amidohydrolase

3

0

High-throughput

0.634

High

957731

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

7

Small-scale

0.633

High

334183

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

4

High-throughput

0.628

High

241608

PRKN
E3 ubiquitin-protein ligase parkin

2

14

Small-scale

0.624

High

157334

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.618

High

214426

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

17

Small-scale

0.618

High

282584

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

7

Small-scale

0.618

High

363244

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

834749

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

19

Small-scale

0.618

High

835665

KPCI
Protein kinase C iota type

1

20

Small-scale

0.618

High

1109602

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.618

High

1109616

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1109627

MLKL
Mixed lineage kinase domain-like protein

1

17

Small-scale

0.618

High

1109641

TNR25
Tumor necrosis factor receptor superfamily member 25

1

18

Small-scale

0.618

High

1109658

CARD6
Caspase recruitment domain-containing protein 6

1

12

Small-scale

0.618

High

1109669

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

9

Small-scale

0.618

High

402922

ANXA1
Annexin A1

2

3

Small-scale

0.612

High

1094534

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

11

Small-scale

0.612

High

1109601

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

8

Small-scale

0.611

High

1109643

MIB2
E3 ubiquitin-protein ligase MIB2

2

20

Small-scale

0.611

High

1109694

AP1M2
AP-1 complex subunit mu-2

2

5

High-throughput

0.611

High

1109611

DAB2P
Disabled homolog 2-interacting protein

2

18

Small-scale

0.601

High

1109639

CASPA
Caspase-10

2

8

Small-scale

0.601

High

1109660

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

5

Small-scale

0.601

High

1109679

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

8

Small-scale

0.595

High

136689

TRAF5
TNF receptor-associated factor 5

2

20

Small-scale

0.584

High

897140

TNF10
Tumor necrosis factor ligand superfamily member 10

2

8

Small-scale

0.584

High

986401

PPIA
Peptidyl-prolyl cis-trans isomerase A

2

6

High-throughput

0.584

High

1099857

TIF1B
Transcription intermediary factor 1-beta

2

9

Small-scale

0.584

High

1109618

MAVS
Mitochondrial antiviral-signaling protein

2

14

Small-scale

0.584

High

1109647

RNF31
E3 ubiquitin-protein ligase RNF31

2

5

Small-scale

0.584

High

1109651

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

13

Small-scale

0.584

High

1109665

EGLN3
Prolyl hydroxylase EGLN3

2

3

Small-scale

0.584

High

231569

PRKY
Putative serine/threonine-protein kinase PRKY

1

13

High-throughput

0.575

High

1109609

OTUD1
OTU domain-containing protein 1

2

7

Small-scale

0.575

High

1109614

THSD4
Thrombospondin type-1 domain-containing protein 4

2

2

High-throughput

0.574

High

1109653

GPX7
Glutathione peroxidase 7

2

2

High-throughput

0.574

High

130743

TAF4
Transcription initiation factor TFIID subunit 4

2

7

High-throughput

0.571

High

347005

BAG2
BAG family molecular chaperone regulator 2

2

5

High-throughput

0.571

High

415545

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

452252

PDIA1
Protein disulfide-isomerase

2

12

High-throughput

0.571

High

686810

S10A4
Protein S100-A4

2

1

High-throughput

0.571

High

709120

TPP2
Tripeptidyl-peptidase 2

2

1

High-throughput

0.571

High

959149

ABCE1
ATP-binding cassette sub-family E member 1

2

5

High-throughput

0.571

High

987013

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

6

High-throughput

0.571

High

992474

RS21
Small ribosomal subunit protein eS21

2

1

High-throughput

0.571

High

1109624

CCAR2
Cell cycle and apoptosis regulator protein 2

2

1

High-throughput

0.571

High

1109635

PHLA1
Pleckstrin homology-like domain family A member 1

2

4

High-throughput

0.571

High

1109656

ANM1
Protein arginine N-methyltransferase 1

2

4

High-throughput

0.571

High

1109657

NADAP
Kanadaptin

2

2

High-throughput

0.571

High

1109671

ARGL1
Arginine and glutamate-rich protein 1

2

1

High-throughput

0.571

High

1109686

TR150
Thyroid hormone receptor-associated protein 3

2

11

High-throughput

0.571

High

764728

CTNB1
Catenin beta-1

1

10

Small-scale

0.561

High

1059823

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

8

Small-scale

0.561

High

1109615

TRI72
Tripartite motif-containing protein 72

1

14

Small-scale

0.561

High

1109623

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

Small-scale

0.561

High

1109636

RFFL
E3 ubiquitin-protein ligase rififylin

1

20

Small-scale

0.561

High

1109684

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

13

Small-scale

0.561

High

1064983

FGL1
Fibrinogen-like protein 1

2

1

High-throughput

0.558

High

571959

TRI27
Zinc finger protein RFP

1

14

Small-scale

0.554

High

476674

RSSA
Small ribosomal subunit protein uS2

2

0

High-throughput

0.547

High

974378

SMD1
Small nuclear ribonucleoprotein Sm D1

2

0

High-throughput

0.547

High

974542

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

High-throughput

0.547

High

1012689

RT06
Small ribosomal subunit protein bS6m

2

0

High-throughput

0.547

High

1109685

RT17
Small ribosomal subunit protein uS17m

2

0

High-throughput

0.547

High

1109664

PPDPF
Pancreatic progenitor cell differentiation and proliferation factor

1

0

Small-scale

0.537

High

64865

RCCD1
RCC1 domain-containing protein 1

1

7

High-throughput

0.536

High

220083

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

1

High-throughput

0.536

High

359811

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

445175

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

542502

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

700624

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

700879

PSB4
Proteasome subunit beta type-4

1

8

High-throughput

0.536

High

767088

SPB6
Serpin B6

1

7

High-throughput

0.536

High

777454

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.536

High

853250

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

1109597

NBR1
Next to BRCA1 gene 1 protein

1

2

High-throughput

0.536

High

1109622

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1109625

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

1109637

RPGF5
Rap guanine nucleotide exchange factor 5

1

5

High-throughput

0.536

High

1109644

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1109659

DUS16
Dual specificity protein phosphatase 16

1

11

High-throughput

0.536

High

1109661

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1109666

CNO10
CCR4-NOT transcription complex subunit 10

1

2

High-throughput

0.536

High

1109667

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

1109678

HSPB8
Heat shock protein beta-8

1

5

High-throughput

0.536

High

1109687

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.536

High

1109621

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.534

High

214802

HNRPR
Heterogeneous nuclear ribonucleoprotein R

2

1

High-throughput

0.521

High

1109631

RP9
Retinitis pigmentosa 9 protein

2

1

High-throughput

0.521

High

1109681

SRRM2
Serine/arginine repetitive matrix protein 2

2

13

High-throughput

0.521

High

298167

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

501981

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

1109617

BOP
Protein Bop

1

0

High-throughput

0.513

High

1109630

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

142680

TRI38
E3 ubiquitin-protein ligase TRIM38

1

14

Small-scale

0.506

High

1109674

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.501

High

1109633

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

Small-scale

0.493

High

649309

H1T
Histone H1t

1

4

High-throughput

0.489

High

1109603

INF2
Inverted formin-2

1

5

High-throughput

0.489

High

1109626

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

10

High-throughput

0.489

High

1109682

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.489

High

1109695

NUMBL
Numb-like protein

1

11

High-throughput

0.481

High

1109610

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.480

High

67128

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

4

Small-scale

0.479

High

172788

XPO1
Exportin-1

1

13

High-throughput

0.479

High

302511

RNF8
E3 ubiquitin-protein ligase RNF8

1

13

Small-scale

0.479

High

317170

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

3

Small-scale

0.479

High

342859

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

High-throughput

0.479

High

408052

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

424887

ADT2
ADP/ATP translocase 2

1

12

High-throughput

0.479

High

457416

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

487280

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

520574

RARA
Retinoic acid receptor alpha

1

3

Small-scale

0.479

High

535030

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

537112

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

623328

RO52
E3 ubiquitin-protein ligase TRIM21

1

14

Small-scale

0.479

High

630271

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

18

Small-scale

0.479

High

642852

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

651316

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

697526

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

727793

DNJA1
DnaJ homolog subfamily A member 1

1

20

High-throughput

0.479

High

761388

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

801305

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

830692

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

981817

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

993166

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.479

High

1109599

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1109605

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

High-throughput

0.479

High

1109607

BRDT
Bromodomain testis-specific protein

1

9

High-throughput

0.479

High

1109612

XAF1
XIAP-associated factor 1

1

4

Small-scale

0.479

High

1109632

WDR48
WD repeat-containing protein 48

1

10

Small-scale

0.479

High

1109638

TANK
TRAF family member-associated NF-kappa-B activator

1

1

Small-scale

0.479

High

1109640

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

1109646

CLIP3
CAP-Gly domain-containing linker protein 3

1

10

Small-scale

0.479

High

1109648

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

17

High-throughput

0.479

High

1109650

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.479

High

1109663

ATG5
Autophagy protein 5

1

1

Small-scale

0.479

High

1109676

UBQL2
Ubiquilin-2

1

7

High-throughput

0.479

High

1109677

XPO7
Exportin-7

1

10

High-throughput

0.479

High

1109683

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

1109689

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

Small-scale

0.479

High

634104

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

Small-scale

0.458

High

1109628

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

695391

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.457

High

377889

TNFB
Lymphotoxin-alpha

1

8

Small-scale

0.445

High

906659

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

7

Small-scale

0.445

High

1109596

RCN2
Reticulocalbin-2

1

10

High-throughput

0.437

High

1109606

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

4

High-throughput

0.437

High

1109652

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

1

Small-scale

0.437

High

1109688

RNF11
RING finger protein 11

1

9

Small-scale

0.437

High

261493

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

1109604

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1109634

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1109613

ANGL8
Angiopoietin-like protein 8

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025