Interactor 1: NOP56 (O00567)
Nucleolar protein 56 (Nucleolar protein 5A)
Gene: NOP56

Interactor 2: FBRL (P22087)
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)
Gene: FBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 26496610, 34079125, 37071682, 26186194, 28514442, 29568061, 33961781, 35271311, 17636026, unassigned1655
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Fibrillarin~Nop, Fibrillarin~NOP5NT
Common GO terms GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
and 4 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 594
Hs

1 321
+ Hs
+ Ce
+ Sc
+ Sc
+ Ca
+ Ss
+ Pf
+ Af

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024