HitPredict

Interactor 1: TRI45 (Q9H8W5)
E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)
Gene: TRIM45

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	35217833, 36681779
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 580 Hs			1 693
+	Mm
		1161351 TRI45_MOUSE (1-580): 2.35e-170: 497: 86.03		TAB2_MOUSE (1-693): 7.87e-108: 344: 94.66
+	Hs
		537101 TRI27_HUMAN (130-570): 4.55e-76: 252: 16.06		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		135043 TRI38_HUMAN (125-521): 7.67e-74: 244: 13.52		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		1318714 TRIM5_HUMAN (131-518): 1.26e-72: 242: 15.96		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		1223392 TRI22_HUMAN (121-552): 2.18e-69: 234: 13.01		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		536926 TRI27_HUMAN (130-570): 4.55e-76: 252: 16.06		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		135034 TRI38_HUMAN (125-521): 7.67e-74: 244: 13.52		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		1234340 TRIM5_HUMAN (131-518): 1.26e-72: 242: 15.96		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Mm
		1111935 TIF1B_MOUSE (28-413): 1.93e-62: 222: 19.85		SMCA4_MOUSE (201-665): 3.01e-44: 173: 11.52
+	Hs
		980027 TRI33_HUMAN (28-400): 2.6e-69: 244: 25.20		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28
+	Hs
		537122 TRI27_HUMAN (130-570): 4.55e-76: 252: 16.06		MAGL2_HUMAN (37-544): 1.37e-09: 63.6: 8.02
+	Hs
		846897 TRI33_HUMAN (28-400): 2.6e-69: 244: 25.20		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		170182 TIF1A_HUMAN (10-401): 3.18e-68: 241: 22.64		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		847115 TRI33_HUMAN (28-400): 2.6e-69: 244: 25.20		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Ce
		136810 LIN41_CAEEL (56-524): 1.56e-60: 219: 16.78		UNC89_CAEEL (139-525): 1.99e-16: 86.3: 9.35
+	Hs
		170402 TIF1A_HUMAN (10-401): 3.18e-68: 241: 22.64		SRCAP_HUMAN (28-590): 2.21e-09: 63.2: 8.69
+	Hs
		846767 TIF1B_HUMAN (28-402): 4.13e-61: 218: 19.53		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257607 TIF1B_HUMAN (28-402): 4.13e-61: 218: 19.53		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		846956 TIF1B_HUMAN (28-402): 4.13e-61: 218: 19.53		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		1170080 TRI54_HUMAN (6-371): 1.13e-57: 198: 16.03		SRCAP_HUMAN (28-590): 2.21e-09: 63.2: 8.69