Protein: PCSK5
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)

Gene: PCSK5
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q92824

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001822 - kidney development
GO:0002001 - renin secretion into blood stream
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

709075

PCSK6
Proprotein convertase subtilisin/kexin type 6

2

20

High-throughput

0.783

High

1144647

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

8

High-throughput

0.770

High

1311449

TRI42
Tripartite motif-containing protein 42

2

10

High-throughput

0.700

High

731887

CEAM8
Cell adhesion molecule CEACAM8

1

9

High-throughput

0.691

High

1060900

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

11

High-throughput

0.691

High

1042656

UPAR
Urokinase plasminogen activator surface receptor

3

1

High-throughput

0.667

High

1369102

GPHA2
Glycoprotein hormone alpha-2

3

1

High-throughput

0.667

High

1277341

NT2NA
Notch homolog 2 N-terminal-like protein A

2

19

High-throughput

0.633

High

479072

CEL3A
Chymotrypsin-like elastase family member 3A

2

5

High-throughput

0.628

High

567940

PRG2
Bone marrow proteoglycan

2

13

High-throughput

0.628

High

1324263

LYPD1
Ly6/PLAUR domain-containing protein 1

2

3

High-throughput

0.628

High

1369117

PRG3
Proteoglycan 3

2

12

High-throughput

0.628

High

168440

NCTR3
Natural cytotoxicity triggering receptor 3

1

4

High-throughput

0.618

High

685921

KRA59
Keratin-associated protein 5-9

3

10

High-throughput

0.616

High

950611

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.616

High

1277877

NUFP2
FMR1-interacting protein NUFIP2

3

2

High-throughput

0.616

High

1034792

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

1

High-throughput

0.609

High

221383

SPY1
Protein sprouty homolog 1

2

3

High-throughput

0.606

High

604844

HXB9
Homeobox protein Hox-B9

2

5

High-throughput

0.606

High

1086980

PO4F2
POU domain, class 4, transcription factor 2

2

3

High-throughput

0.606

High

1250275

ATL4
ADAMTS-like protein 4

2

8

High-throughput

0.606

High

1365423

DOCK2
Dedicator of cytokinesis protein 2

2

1

High-throughput

0.606

High

1369105

TRAF4
TNF receptor-associated factor 4

2

9

High-throughput

0.606

High

192121

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

1248568

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.602

High

1369118

INSL5
Insulin-like peptide INSL5

2

0

High-throughput

0.602

High

733192

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.580

High

894068

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.578

High

291846

STK16
Serine/threonine-protein kinase 16

1

2

High-throughput

0.573

High

885356

HXA1
Homeobox protein Hox-A1

2

6

High-throughput

0.553

High

948368

KR122
Keratin-associated protein 12-2

2

7

High-throughput

0.553

High

950850

KR109
Keratin-associated protein 10-9

2

9

High-throughput

0.553

High

1059708

KRA11
Keratin-associated protein 1-1

2

9

High-throughput

0.553

High

1061800

TLE5
TLE family member 5

2

1

High-throughput

0.553

High

1151033

PCH2
Pachytene checkpoint protein 2 homolog

2

2

High-throughput

0.553

High

1258156

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

1

High-throughput

0.553

High

1309040

ZN547
Zinc finger protein 547

2

14

High-throughput

0.553

High

1330200

ZN655
Zinc finger protein 655

2

11

High-throughput

0.553

High

1364908

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

6

High-throughput

0.553

High

1369099

ZN837
Zinc finger protein 837

2

8

High-throughput

0.553

High

1369101

TRIB3
Tribbles homolog 3

2

3

High-throughput

0.553

High

1369106

LCE3D
Late cornified envelope protein 3D

2

1

High-throughput

0.553

High

1369107

KRA32
Keratin-associated protein 3-2

2

1

High-throughput

0.553

High

1369108

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

224510

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

316683

LY6H
Lymphocyte antigen 6H

1

1

High-throughput

0.536

High

342636

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

506887

CFC1
Cryptic protein

1

5

High-throughput

0.536

High

518886

CCL3
C-C motif chemokine 3

1

2

High-throughput

0.536

High

933206

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

2

High-throughput

0.536

High

1030202

IL5RA
Interleukin-5 receptor subunit alpha

1

8

High-throughput

0.536

High

1249678

IGFL3
Insulin growth factor-like family member 3

1

5

High-throughput

0.536

High

1308275

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

4

High-throughput

0.536

High

1359218

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.536

High

1369110

CST9L
Cystatin-9-like

1

4

High-throughput

0.536

High

1369119

ST14
Suppressor of tumorigenicity 14 protein

1

8

High-throughput

0.536

High

300205

GLRX3
Glutaredoxin-3

1

6

High-throughput

0.523

High

950355

KR107
Keratin-associated protein 10-7

1

9

High-throughput

0.523

High

1369104

KR412
Keratin-associated protein 4-12

1

7

High-throughput

0.523

High

517077

NT2NC
Notch homolog 2 N-terminal-like protein C

1

19

High-throughput

0.515

High

351839

BY55
CD160 antigen

1

0

High-throughput

0.513

High

639278

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

High-throughput

0.489

High

1101291

SLAF1
Signaling lymphocytic activation molecule

1

9

High-throughput

0.489

High

1177855

CL12B
C-type lectin domain family 12 member B

1

8

High-throughput

0.489

High

1369097

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.489

High

1369098

SPSB4
SPRY domain-containing SOCS box protein 4

1

7

High-throughput

0.489

High

1369111

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.489

High

1369115

DNJB9
DnaJ homolog subfamily B member 9

1

7

High-throughput

0.489

High

1369116

FBX2
F-box only protein 2

1

9

High-throughput

0.489

High

1369120

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.489

High

1356081

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

5

High-throughput

0.481

High

1232498

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1237996

Q6NSM0
NR1D2 protein

1

8

High-throughput

0.470

High

139732

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

4

High-throughput

0.464

High

928310

ATN1
Atrophin-1

1

8

High-throughput

0.464

High

595

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.439

High

949957

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.439

High

1134834

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

4

High-throughput

0.439

High

1215051

LCE3A
Late cornified envelope protein 3A

1

1

High-throughput

0.439

High

1212911

LCE3C
Late cornified envelope protein 3C

3

0

High-throughput

0.352

High

70399

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

71134

VGLL3
Transcription cofactor vestigial-like protein 3

2

0

High-throughput

0.316

High

220289

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

334448

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

892228

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

1039790

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.316

High

1081426

INCA1
Protein INCA1

2

0

High-throughput

0.316

High

1186529

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1187732

KR133
Keratin-associated protein 13-3

2

0

High-throughput

0.316

High

1213957

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

1214044

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

1215189

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

1242988

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1307052

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1339486

DBF4B
Protein DBF4 homolog B

2

0

High-throughput

0.316

High

1358945

CQ050
Uncharacterized protein C17orf50

2

0

High-throughput

0.316

High

1358978

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1369100

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1369103

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1369112

PLS4
Phospholipid scramblase 4

2

0

High-throughput

0.316

High

1369113

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.316

High

1369114

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

1365948

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.282

High

1150554

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

1369109

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

1328377

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025