Protein: FBXW5
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)

Gene: FBXW5
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q969U6

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007088 - regulation of mitotic nuclear division
GO:0010824 - regulation of centrosome duplication
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

929023

SKP1
S-phase kinase-associated protein 1

15

1

Small-scale

0.983

High

1041137

CUL1
Cullin-1

9

4

Small-scale

0.968

High

1043150

CUL4A
Cullin-4A

4

4

Small-scale

0.881

High

1082318

DDB1
DNA damage-binding protein 1

4

1

Small-scale

0.878

High

1253154

WDR20
WD repeat-containing protein 20

3

0

High-throughput

0.822

High

1032858

PHLP
Phosducin-like protein

1

1

High-throughput

0.691

High

1041427

CUL2
Cullin-2

1

4

High-throughput

0.691

High

1043501

CUL4B
Cullin-4B

1

4

High-throughput

0.691

High

1129894

DCA10
DDB1- and CUL4-associated factor 10

1

1

High-throughput

0.691

High

1282430

IF122
Intraflagellar transport protein 122 homolog

1

1

High-throughput

0.691

High

889615

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.675

High

1071318

K1H1
Keratin, type I cuticular Ha1

3

3

High-throughput

0.675

High

309508

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.656

High

580442

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

0

High-throughput

0.656

High

921678

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.656

High

1016139

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.656

High

1061543

CUL7
Cullin-7

1

0

High-throughput

0.656

High

1078046

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.656

High

1104136

EMAL3
Echinoderm microtubule-associated protein-like 3

1

0

High-throughput

0.656

High

1162290

WDR59
GATOR2 complex protein WDR59

1

0

High-throughput

0.656

High

1234362

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.656

High

1253564

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.656

High

1282425

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.655

High

536966

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

1242073

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

3

0

High-throughput

0.638

High

1282410

HSPB9
Heat shock protein beta-9

3

0

High-throughput

0.638

High

1189390

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.633

High

1282422

NDEL1
Nuclear distribution protein nudE-like 1

2

1

High-throughput

0.628

High

1174517

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.622

High

1042224

CUL3
Cullin-3

1

4

Small-scale

0.618

High

1282404

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.618

High

573408

TCPA
T-complex protein 1 subunit alpha

2

3

High-throughput

0.611

High

770970

TCPZ
T-complex protein 1 subunit zeta

2

4

High-throughput

0.611

High

943396

TCPB
T-complex protein 1 subunit beta

2

4

High-throughput

0.611

High

280680

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.606

High

280901

KRT37
Keratin, type I cuticular Ha7

2

3

High-throughput

0.606

High

889858

KR109
Keratin-associated protein 10-9

2

10

High-throughput

0.606

High

1127097

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.606

High

1216368

KRA13
Keratin-associated protein 1-3

2

9

High-throughput

0.606

High

1282417

KRA93
Keratin-associated protein 9-3

2

9

High-throughput

0.606

High

1282418

KRA41
Keratin-associated protein 4-1

2

9

High-throughput

0.606

High

1282439

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

1

High-throughput

0.606

High

422435

NFM
Neurofilament medium polypeptide

2

0

High-throughput

0.602

High

1102713

TXIP1
Translin-associated factor X-interacting protein 1

2

0

High-throughput

0.602

High

1017418

CDC20
Cell division cycle protein 20 homolog

1

0

Small-scale

0.586

High

1260860

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.586

High

1282433

DCA13
DDB1- and CUL4-associated factor 13

1

0

Small-scale

0.586

High

835094

TSC2
Tuberin

2

1

Small-scale

0.584

High

888606

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.580

High

201388

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

0

Small-scale

0.576

High

1149270

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.573

High

1282416

KRA94
Keratin-associated protein 9-4

1

9

High-throughput

0.573

High

921380

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.569

High

1261691

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

2

0

Small-scale

0.559

High

328028

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

1

High-throughput

0.553

High

957281

FBLN2
Fibulin-2

2

1

High-throughput

0.553

High

1102891

VWC2
Brorin

2

1

High-throughput

0.553

High

1282408

KR412
Keratin-associated protein 4-12

1

9

High-throughput

0.541

High

1164968

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

Small-scale

0.537

High

147276

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

381264

TBB4A
Tubulin beta-4A chain

1

3

High-throughput

0.536

High

428352

TBB5
Tubulin beta chain

1

3

High-throughput

0.536

High

826810

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.536

High

933559

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

1023308

TRI32
E3 ubiquitin-protein ligase TRIM32

1

2

High-throughput

0.536

High

1037344

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

1040767

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.536

High

1114179

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.536

High

1133451

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

1175081

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.536

High

1266387

TCPW
T-complex protein 1 subunit zeta-2

1

5

High-throughput

0.536

High

1282406

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.536

High

1282409

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.536

High

1282413

AFG2B
ATPase family gene 2 protein homolog B

1

1

High-throughput

0.536

High

1282405

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

1267513

TSC1
Hamartin

1

1

Small-scale

0.515

High

243534

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.513

High

304281

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.513

High

323942

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

504529

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

658406

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

1079209

STXB2
Syntaxin-binding protein 2

1

0

High-throughput

0.513

High

1128114

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.513

High

1140681

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.513

High

1150623

MRCKG
Serine/threonine-protein kinase MRCK gamma

1

0

High-throughput

0.513

High

1161933

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.513

High

1163778

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

1224565

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.513

High

1229683

FCSK
L-fucose kinase

1

0

High-throughput

0.513

High

1244814

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

1282399

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.513

High

1282401

GCP6
Gamma-tubulin complex component 6

1

0

High-throughput

0.513

High

1282407

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1282411

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.513

High

1282415

BBS2
Bardet-Biedl syndrome 2 protein

1

0

High-throughput

0.513

High

1282419

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

1282421

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.513

High

1282424

SAV1
Protein salvador homolog 1

1

0

High-throughput

0.513

High

1282426

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.513

High

1282427

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.513

High

1282432

CABP2
Calcium-binding protein 2

1

0

High-throughput

0.513

High

1282434

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.513

High

1282440

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

1282442

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

1282444

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.513

High

1074067

SC23B
Protein transport protein Sec23B

1

0

Small-scale

0.505

High

1109344

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1282402

IF140
Intraflagellar transport protein 140 homolog

1

1

High-throughput

0.489

High

380830

S100B
Protein S100-B

1

0

High-throughput

0.486

High

888955

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.481

High

991640

KRA11
Keratin-associated protein 1-1

1

8

High-throughput

0.481

High

1024202

CSN1
COP9 signalosome complex subunit 1

1

0

Small-scale

0.479

High

1282412

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.479

High

136060

ACACB
Acetyl-CoA carboxylase 2

1

2

High-throughput

0.479

High

323441

TTC4
Tetratricopeptide repeat protein 4

1

2

High-throughput

0.479

High

325839

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.479

High

398281

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.479

High

398385

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.479

High

432133

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

438415

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

513616

PYC
Pyruvate carboxylase, mitochondrial

1

2

High-throughput

0.479

High

821349

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

839965

F10A1
Hsc70-interacting protein

1

1

High-throughput

0.479

High

1217417

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1261388

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1282431

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.479

High

1282435

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

1282441

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

484680

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

596

NBPFJ
Neuroblastoma breakpoint family member 19

1

0

High-throughput

0.460

High

118775

AIP
AH receptor-interacting protein

1

0

High-throughput

0.458

High

129033

PLK4
Serine/threonine-protein kinase PLK4

1

0

Small-scale

0.458

High

163097

XPO1
Exportin-1

1

0

High-throughput

0.458

High

171661

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.458

High

449337

LEG1
Galectin-1

1

0

High-throughput

0.458

High

486821

MYB
Transcriptional activator Myb

1

0

Small-scale

0.458

High

551799

DESP
Desmoplakin

1

0

High-throughput

0.458

High

598262

FLNA
Filamin-A

1

0

High-throughput

0.458

High

858660

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

927855

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

1025057

REST
RE1-silencing transcription factor

1

0

Small-scale

0.458

High

1067784

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.458

High

1082180

CSRP2
Cysteine and glycine-rich protein 2

1

0

High-throughput

0.458

High

1173701

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.458

High

1199960

NOXA1
NADPH oxidase activator 1

1

0

High-throughput

0.458

High

1273380

GLMN
Glomulin

1

0

High-throughput

0.458

High

1282400

RHG07
Rho GTPase-activating protein 7

1

0

Small-scale

0.458

High

1282403

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

1282428

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.458

High

1282429

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1282438

NLK
Serine/threonine-protein kinase NLK

1

0

Small-scale

0.458

High

1245620

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

211309

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

1166951

ATL4
ADAMTS-like protein 4

3

0

High-throughput

0.352

High

1109869

CMA1D
Protein CIMAP1D

3

0

High-throughput

0.347

High

1243157

SRFB1
Serum response factor-binding protein 1

3

0

High-throughput

0.347

High

887756

DEFB1
Beta-defensin 1

2

0

High-throughput

0.328

High

67273

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

58368

CI170
Uncharacterized protein encoded by LINC02872

1

0

High-throughput

0.279

Low

1020387

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

Small-scale

0.279

Low

1101818

WASC4
WASH complex subunit 4

1

0

High-throughput

0.279

Low

1145622

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1158745

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.279

Low

1169247

ZN704
Zinc finger protein 704

1

0

High-throughput

0.279

Low

1204123

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

1282414

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

1282420

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

1282423

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1282436

ZNFX1
NFX1-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

1282443

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.279

Low

1267370

F168A
Protein FAM168A

1

0

High-throughput

0.265

Low

708722

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.249

Low

1282437

NYNRI
Protein NYNRIN

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024