HitPredict

Interactor 1: RRAGC (Q9HB90)
Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)
Gene: RRAGC

Interactor 2: LTOR3 (Q9UHA4)
Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)
Gene: LAMTOR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	20381137, 33961781, 25561175
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0008104 - protein localization GO:0071230 - cellular response to amino acid stimulus GO:1904263 - positive regulation of TORC1 signaling GO:1990877 - FNIP-folliculin RagC/D GAP
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 124
+	Hs
		1343498 RRAGD_HUMAN (25-396): 0: 527: 80.91		LTOR3_HUMAN (1-124): 3.04e-72: 212: 100.00
+	Hs
		1184618 RRAGA_HUMAN (53-284): 3.26e-105: 314: 26.27		LTOR3_HUMAN (1-124): 3.04e-72: 212: 100.00
+	Hs
		1139781 RRAGB_HUMAN (43-284): 9.91e-104: 313: 24.09		LTOR3_HUMAN (1-124): 3.04e-72: 212: 100.00
+	Mm
		292054 RRAGA_MOUSE (53-284): 3.26e-105: 314: 26.27		LTOR3_MOUSE (1-124): 4.72e-71: 209: 97.58