Protein: LEMD2
LEM domain-containing protein 2 (hLEM2)

Gene: LEMD2
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q8NC56

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005737 - cytoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

385983

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

5

Small-scale

0.676

High

1052794

ACHB3
Neuronal acetylcholine receptor subunit beta-3

3

7

High-throughput

0.667

High

722541

CTR1
High affinity cationic amino acid transporter 1

3

2

High-throughput

0.662

High

733710

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

3

7

High-throughput

0.662

High

1242871

S39A4
Zinc transporter ZIP4

5

5

High-throughput

0.648

High

1010074

DLK1
Protein delta homolog 1

3

0

High-throughput

0.638

High

1335166

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

7

High-throughput

0.609

High

855354

5HT3A
5-hydroxytryptamine receptor 3A

3

9

High-throughput

0.604

High

1086049

ASPH
Aspartyl/asparaginyl beta-hydroxylase

3

1

High-throughput

0.604

High

1335159

S39A8
Metal cation symporter ZIP8

3

5

High-throughput

0.604

High

878057

AGRE5
Adhesion G protein-coupled receptor E5

2

0

High-throughput

0.602

High

1032622

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.602

High

1195361

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

851177

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

5

High-throughput

0.601

High

1335145

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

1

High-throughput

0.601

High

1335150

TM169
Transmembrane protein 169

2

0

High-throughput

0.576

High

539725

ACHB
Acetylcholine receptor subunit beta

2

7

High-throughput

0.549

High

125034

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.536

High

132629

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

166171

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

173998

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.536

High

470321

NEP
Neprilysin

1

1

High-throughput

0.536

High

595080

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.536

High

648830

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

3

High-throughput

0.536

High

723245

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

7

High-throughput

0.536

High

818878

ADCY8
Adenylate cyclase type 8

1

1

High-throughput

0.536

High

1022426

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.536

High

1157135

KCA10
Potassium voltage-gated channel subfamily A member 10

1

3

High-throughput

0.536

High

1335144

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

1335149

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1335156

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.536

High

1335161

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

1335162

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

137465

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.513

High

141005

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

250716

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

571621

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

662612

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.513

High

693851

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

1115823

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1126241

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

0

High-throughput

0.513

High

1335155

SORT
Sortilin

1

0

High-throughput

0.513

High

1335167

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

349490

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

1043863

KCNC4
Voltage-gated potassium channel KCNC4

1

2

High-throughput

0.489

High

1197836

S39AC
Zinc transporter ZIP12

1

5

High-throughput

0.489

High

1203731

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.489

High

1335148

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

1335152

TMM74
Transmembrane protein 74

1

1

High-throughput

0.489

High

430141

JUN
Transcription factor Jun

1

1

High-throughput

0.479

High

589183

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

872536

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

980001

H4
Histone H4

1

1

High-throughput

0.479

High

1004842

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1161550

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1254683

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1334466

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1335139

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1335165

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

223184

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

242306

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

629964

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

767267

MERL
Merlin

1

0

High-throughput

0.458

High

851787

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

937823

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

995146

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1140575

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1335146

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.458

High

942754

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

1093551

TRDN
Triadin

1

3

High-throughput

0.445

High

1131574

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1139511

S39AE
Metal cation symporter ZIP14

1

5

High-throughput

0.445

High

1239014

NIPA3
Magnesium transporter NIPA3

1

1

High-throughput

0.445

High

1242173

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.445

High

1325987

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1329279

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.445

High

1335138

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

1335140

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1335143

S39A7
Zinc transporter SLC39A7

1

5

High-throughput

0.445

High

1335164

SL9A2
Sodium/hydrogen exchanger 2

1

2

High-throughput

0.445

High

106292

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

218484

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

695964

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768666

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

967325

TSN5
Tetraspanin-5

1

2

High-throughput

0.437

High

1159210

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.437

High

1249028

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1308162

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

1311943

SKA3
Spindle and kinetochore-associated protein 3

1

1

Small-scale

0.437

High

1323868

SYNE4
Nesprin-4

1

1

High-throughput

0.437

High

303260

S22A5
Organic cation/carnitine transporter 2

1

0

High-throughput

0.426

High

1324738

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.426

High

1335160

SC5A7
High affinity choline transporter 1

1

0

High-throughput

0.426

High

835331

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.407

High

877696

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

1230825

SL9A4
Sodium/hydrogen exchanger 4

1

2

High-throughput

0.407

High

1335141

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.407

High

1335157

HAUS7
HAUS augmin-like complex subunit 7

3

0

High-throughput

0.347

High

1335142

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

0

High-throughput

0.345

High

219335

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

1335151

SGSM3
Small G protein signaling modulator 3

2

0

High-throughput

0.319

High

1335147

SAAL1
Protein SAAL1

2

0

High-throughput

0.313

High

1335153

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.313

High

1327765

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

169195

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

282968

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

1

0

High-throughput

0.279

Low

399598

VTNC
Vitronectin

1

0

High-throughput

0.279

Low

488064

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

1335158

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.279

Low

185860

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

1041679

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

1333291

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1335163

ANLN
Anillin

1

0

High-throughput

0.249

Low

765715

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low

1157180

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1335154

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025