HitPredict

Interactor 1: ARNT2 (Q9HBZ2)
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)
Gene: ARNT2

Interactor 2: X5D985 (X5D985)
Neuronal PAS domain protein 3 isoform F
Gene: NPAS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_3, PAS~PAS_11, PAS_11~PAS_3
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 717 Hs			1 901
+	Hs
		1220557 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS3_HUMAN (1-901): 0: 918: 96.36
+	Hs
		1335647 ARNT2_HUMAN (1-717): 0: 697: 100.00		X5DR67_HUMAN (1-901): 0: 918: 97.39
+	Hs
		1378460 X5D7T2_HUMAN (1-691): 0: 668: 98.99		X5D985_HUMAN (1-901): 0: 929: 100.00
+	Hs
		1220558 X5D7T2_HUMAN (1-691): 0: 668: 98.99		NPAS3_HUMAN (1-901): 0: 918: 96.36
+	Hs
		1378461 X5D7T2_HUMAN (1-691): 0: 668: 98.99		X5DR67_HUMAN (1-901): 0: 918: 97.39
+	Hs
		1378465 X5DP31_HUMAN (1-624): 0: 617: 94.88		X5D985_HUMAN (1-901): 0: 929: 100.00
+	Hs
		1220559 X5DP31_HUMAN (1-624): 0: 617: 94.88		NPAS3_HUMAN (1-901): 0: 918: 96.36
+	Mm
		101520 ARNT_MOUSE (4-717): 0: 546: 56.20		F8VQB2_MOUSE (9-901): 0: 888: 93.73
+	Hs
		1306541 ARNT2_HUMAN (1-717): 0: 697: 100.00		EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67
+	Hs
		1050587 ARNT2_HUMAN (1-717): 0: 697: 100.00		SIM2_HUMAN (21-701): 4.35e-138: 428: 28.85
+	Hs
		1085690 ARNT2_HUMAN (1-717): 0: 697: 100.00		HIF1A_HUMAN (10-590): 6.88e-135: 425: 27.13
+	Hs
		946354 ARNT2_HUMAN (1-717): 0: 697: 100.00		SIM1_HUMAN (21-677): 2.79e-134: 422: 28.68
+	Mm
		1142081 ARNT2_MOUSE (1-717): 0: 683: 97.07		SIM1_MOUSE (21-677): 4.27e-136: 426: 28.68
+	Hs
		1306157 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS1_HUMAN (8-542): 3.57e-117: 371: 44.42
+	Hs
		1306192 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS2_HUMAN (12-730): 1.51e-108: 355: 12.48
+	Hs
		728962 ARNT2_HUMAN (1-717): 0: 697: 100.00		AHR_HUMAN (3-568): 1.38e-105: 348: 21.47
+	Hs
		1085741 X5DP31_HUMAN (1-624): 0: 617: 94.88		HIF1A_HUMAN (10-590): 6.88e-135: 425: 27.13
+	Hs
		1216640 ARNT2_HUMAN (1-717): 0: 697: 100.00		NPAS4_HUMAN (22-723): 1.73e-103: 341: 17.45
+	Mm
		1142531 ARNT2_MOUSE (1-717): 0: 683: 97.07		NPAS4_MOUSE (22-723): 8.55e-104: 342: 17.38
+	Mm
		674910 ARNT_MOUSE (4-717): 0: 546: 56.20		AHR_MOUSE (3-575): 1.67e-105: 348: 20.90