HitPredict

Interactor 1: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Interactor 2: NLRC4 (Q9NPP4)
NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 15107016, 11472070
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, NACHT~NACHT, NACHT~NLRC4_HD, NACHT~NLRC4_HD2, NACHT~NOD2_WH, NLRC4_HD~NOD2_WH
Common GO terms GO:0002221 - pattern recognition receptor signaling pathway
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 5 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1040
Hs

1 1024
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024