Protein: METH
Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase)

Gene: METH, MTR
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q99707

Gene Ontology (top 5):
GO:0000096 - sulfur amino acid metabolic process
GO:0005829 - cytosol
GO:0007399 - nervous system development
GO:0008270 - zinc ion binding
GO:0008705 - methionine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1086381

AKP13
A-kinase anchor protein 13

3

1

High-throughput

0.667

High

1406561

AFG2B
ATPase family gene 2 protein homolog B

2

0

High-throughput

0.602

High

1406571

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1406577

MTRR
Methionine synthase reductase

2

0

Small-scale

0.598

High

1404161

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.585

High

1227335

A16L1
Autophagy-related protein 16-1

2

1

High-throughput

0.571

High

1286377

NEK8
Serine/threonine-protein kinase Nek8

2

1

High-throughput

0.558

High

64899

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

220007

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

359864

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

909154

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

922282

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

1406567

TXNIP
Thioredoxin-interacting protein

1

1

High-throughput

0.536

High

162031

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

0

High-throughput

0.513

High

351797

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

401360

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

549669

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

848064

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

905655

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

911949

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.513

High

1383828

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1406563

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1406568

SRMS
Tyrosine-protein kinase Srms

1

0

High-throughput

0.513

High

1406576

KLH14
Kelch-like protein 14

1

0

High-throughput

0.513

High

842843

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

Small-scale

0.494

High

1143241

PLEC
Plectin

1

0

High-throughput

0.493

High

1152463

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.493

High

186346

RA51B
DNA repair protein RAD51 homolog 2

1

1

High-throughput

0.489

High

366433

FA12
Coagulation factor XII

1

1

High-throughput

0.489

High

1315835

AN13A
Ankyrin repeat domain-containing protein 13A

1

1

High-throughput

0.489

High

1336062

ARRD4
Arrestin domain-containing protein 4

1

1

High-throughput

0.489

High

1406583

EMIL1
EMILIN-1

1

2

High-throughput

0.489

High

508500

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

1114109

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1293654

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.479

High

1406560

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.479

High

1406578

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.479

High

1406579

B9D1
B9 domain-containing protein 1

1

1

High-throughput

0.479

High

174595

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.458

High

342303

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

346238

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

374158

RASN
GTPase NRas

1

0

High-throughput

0.458

High

412502

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

459735

PROF1
Profilin-1

1

0

High-throughput

0.458

High

537775

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

679388

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.458

High

696318

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

789002

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

831304

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

942837

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

984248

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

1106679

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1108077

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1178332

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1229052

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1255224

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1280433

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1327585

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.458

High

1397095

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1397347

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1405829

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1406565

SHRPN
Sharpin

1

0

Small-scale

0.458

High

1406570

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1406572

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1406580

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

1406582

MMAC
Cyanocobalamin reductase / alkylcobalamin dealkylase

1

0

Small-scale

0.458

High

606029

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.426

High

933537

S12A3
Solute carrier family 12 member 3

1

0

High-throughput

0.426

High

955894

GMFB
Glia maturation factor beta

1

0

High-throughput

0.426

High

1125921

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.426

High

1239280

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

190252

MOT4
Monocarboxylate transporter 4

1

1

High-throughput

0.407

High

388661

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.407

High

388792

C1QC
Complement C1q subcomponent subunit C

1

1

High-throughput

0.407

High

628454

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

1253649

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1335689

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1254125

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

1406564

LRC27
Leucine-rich repeat-containing protein 27

2

0

High-throughput

0.313

High

846784

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.279

Low

886309

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.279

Low

1057649

CDK18
Cyclin-dependent kinase 18

1

0

High-throughput

0.279

Low

1091899

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1177076

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1204501

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1204656

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.279

Low

1207253

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1211443

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1329544

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1338476

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.279

Low

1385545

ULK4
Serine/threonine-protein kinase ULK4

1

0

High-throughput

0.279

Low

1401000

PSKH2
Serine/threonine-protein kinase H2

1

0

High-throughput

0.279

Low

1406559

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1406562

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.279

Low

1406575

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

187591

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.269

Low

124458

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

294229

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

589505

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

766788

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

768988

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1119601

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.249

Low

1135781

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1151839

RHOH
Rho-related GTP-binding protein RhoH

1

0

High-throughput

0.249

Low

1233443

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1249151

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1272668

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

1352263

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low

1370656

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

0

High-throughput

0.249

Low

1389149

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

1406569

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

0

High-throughput

0.249

Low

327080

NXPH3
Neurexophilin-3

1

0

High-throughput

0.232

Low

437770

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

754083

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

947480

RAB15
Ras-related protein Rab-15

1

0

High-throughput

0.232

Low

1185866

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1208269

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

1349097

F174A
Membrane protein FAM174A

1

0

High-throughput

0.232

Low

1362048

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.232

Low

1369620

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.232

Low

1406566

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.232

Low

1406573

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.232

Low

1406574

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

1406581

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025