HitPredict

Interactor 1: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	20804422, 19318350
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 757 Hs			1 619
+	Mm
		103632 SMUF1_MOUSE (1-757): 0: 855: 95.24		G5E8L8_MOUSE (1-619): 0: 597: 96.28
+	Hs
		1306382 SMUF1_HUMAN (1-757): 0: 891: 100.00		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		1294887 ITCH_HUMAN (1-757): 0: 733: 31.28		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		808330 NEDD4_HUMAN (93-755): 0: 673: 36.63		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		808243 NEDD4_HUMAN (93-755): 0: 673: 36.63		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		808324 NEDD4_HUMAN (93-755): 0: 673: 36.63		AKT3_HUMAN (292-616): 4.97e-125: 379: 24.47
+	At
		1105338 UPL2_ARATH (265-755): 3.35e-170: 545: 36.33		KIN10_ARATH (355-619): 4.11e-132: 398: 31.84
+	Hs
		1299665 NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		1299609 NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		1299664 NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88		AKT3_HUMAN (292-616): 4.97e-125: 379: 24.47