Protein: S39A8
Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)

Gene: S39A8, SLC39A8
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9C0K1

Gene Ontology (top 5):
GO:0005385 - zinc ion transmembrane transporter activity
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0006351 - DNA-templated transcription
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

333184

VAPB
Vesicle-associated membrane protein-associated protein B/C

3

4

High-throughput

0.662

High

1067039

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

3

4

High-throughput

0.662

High

1350001

SPPL3
Signal peptide peptidase-like 3

2

6

High-throughput

0.628

High

1416633

SGPP1
Sphingosine-1-phosphate phosphatase 1

2

1

High-throughput

0.628

High

483967

HMOX1
Heme oxygenase 1

3

2

High-throughput

0.604

High

847441

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

3

3

High-throughput

0.604

High

1307632

ZDH17
Palmitoyltransferase ZDHHC17

3

1

High-throughput

0.604

High

1335159

LEMD2
LEM domain-containing protein 2

3

5

High-throughput

0.604

High

1401688

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

3

6

High-throughput

0.604

High

1416264

CA043
Protein C1orf43

3

2

High-throughput

0.604

High

1281761

T179B
Transmembrane protein 179B

2

0

High-throughput

0.602

High

1365124

SL9A6
Sodium/hydrogen exchanger 6

2

0

High-throughput

0.602

High

1389752

C1GLC
C1GALT1-specific chaperone 1

2

20

High-throughput

0.574

High

1397765

RMD2
Regulator of microtubule dynamics protein 2

2

3

High-throughput

0.574

High

1421372

TAOK2
Serine/threonine-protein kinase TAO2

2

4

High-throughput

0.574

High

1421375

TMX2
Thioredoxin-related transmembrane protein 2

2

2

High-throughput

0.574

High

1241205

CC033
Protein C3orf33

2

5

High-throughput

0.549

High

1421374

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

6

High-throughput

0.549

High

771085

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

10

High-throughput

0.541

High

189819

STX7
Syntaxin-7

1

10

High-throughput

0.536

High

349558

TSN15
Tetraspanin-15

1

8

High-throughput

0.536

High

420041

B3A2
Anion exchange protein 2

1

1

High-throughput

0.536

High

560997

GP1BB
Platelet glycoprotein Ib beta chain

1

6

High-throughput

0.536

High

1087272

STX4
Syntaxin-4

1

10

High-throughput

0.536

High

1369303

EDA
Ectodysplasin-A

1

2

High-throughput

0.536

High

1384627

S67A1
Solute carrier family 67 member A1

1

9

High-throughput

0.536

High

1421373

VANG2
Vang-like protein 2

1

0

High-throughput

0.513

High

136545

GOLI4
Golgi integral membrane protein 4

1

10

High-throughput

0.489

High

699093

CALX
Calnexin

1

6

High-throughput

0.489

High

1254307

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

1

High-throughput

0.489

High

1293355

CHSS1
Chondroitin sulfate synthase 1

1

20

High-throughput

0.489

High

1421369

EXTL2
Exostosin-like 2

1

12

High-throughput

0.489

High

165086

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.445

High

230839

EXTL3
Exostosin-like 3

1

12

High-throughput

0.445

High

249517

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

7

High-throughput

0.445

High

327438

ZFPL1
Zinc finger protein-like 1

1

7

High-throughput

0.445

High

338650

AGRL2
Adhesion G protein-coupled receptor L2

1

10

High-throughput

0.445

High

648309

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

9

High-throughput

0.445

High

908049

VAMP7
Vesicle-associated membrane protein 7

1

3

High-throughput

0.445

High

957005

CXCR4
C-X-C chemokine receptor type 4

1

15

High-throughput

0.445

High

1105774

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

10

High-throughput

0.445

High

1212500

MRP7
ATP-binding cassette sub-family C member 10

1

3

High-throughput

0.445

High

1252833

NFXL1
NF-X1-type zinc finger protein NFXL1

1

9

High-throughput

0.445

High

1253795

QSOX2
Sulfhydryl oxidase 2

1

13

High-throughput

0.445

High

1326223

PNKD
Probable thioesterase PNKD

1

4

High-throughput

0.445

High

1333493

GOLM1
Golgi membrane protein 1

1

7

High-throughput

0.445

High

1382718

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.445

High

1395932

DNJC1
DnaJ homolog subfamily C member 1

1

7

High-throughput

0.445

High

1401075

XPO6
Exportin-6

1

1

High-throughput

0.445

High

1405044

SORT
Sortilin

1

4

High-throughput

0.445

High

1413053

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

2

High-throughput

0.445

High

1418029

FUT8
Alpha-(1,6)-fucosyltransferase

1

4

High-throughput

0.445

High

1421355

GBA2
Non-lysosomal glucosylceramidase

1

1

High-throughput

0.445

High

1421359

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

13

High-throughput

0.445

High

1421361

T106B
Transmembrane protein 106B

1

7

High-throughput

0.445

High

1421364

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

1

High-throughput

0.445

High

1197703

MIDN
Midnolin

1

1

High-throughput

0.437

High

71643

ELAP2
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2

1

0

High-throughput

0.426

High

168898

PLD2
Phospholipase D2

1

0

High-throughput

0.426

High

1358442

LMBR1
Limb region 1 protein homolog

1

0

High-throughput

0.426

High

74060

MYO9A
Unconventional myosin-IXa

1

2

High-throughput

0.407

High

155619

NEMP1
Nuclear envelope integral membrane protein 1

1

1

High-throughput

0.407

High

212600

GPAA1
GPI-anchor transamidase component GPAA1

1

1

High-throughput

0.407

High

249265

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

10

High-throughput

0.407

High

269051

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

9

High-throughput

0.407

High

316562

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

7

High-throughput

0.407

High

329351

LETM1
Mitochondrial proton/calcium exchanger protein

1

7

High-throughput

0.407

High

469193

SRPRA
Signal recognition particle receptor subunit alpha

1

7

High-throughput

0.407

High

471692

CY1
Cytochrome c1, heme protein, mitochondrial

1

4

High-throughput

0.407

High

485894

COX6C
Cytochrome c oxidase subunit 6C

1

2

High-throughput

0.407

High

611331

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

12

High-throughput

0.407

High

895290

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

8

High-throughput

0.407

High

941966

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.407

High

1091978

SEC20
Vesicle transport protein SEC20

1

2

High-throughput

0.407

High

1119457

CASP
Protein CASP

1

16

High-throughput

0.407

High

1138998

TRAM2
Translocating chain-associated membrane protein 2

1

8

High-throughput

0.407

High

1218272

DIK1B
Divergent protein kinase domain 1B

1

5

High-throughput

0.407

High

1238369

RETST
All-trans-retinol 13,14-reductase

1

5

High-throughput

0.407

High

1241161

LTMD1
LETM1 domain-containing protein 1

1

7

High-throughput

0.407

High

1258459

CHSS3
Chondroitin sulfate synthase 3

1

20

High-throughput

0.407

High

1286299

GALT7
N-acetylgalactosaminyltransferase 7

1

20

High-throughput

0.407

High

1286507

SCD5
Stearoyl-CoA desaturase 5

1

4

High-throughput

0.407

High

1291484

RETR3
Reticulophagy regulator 3

1

3

High-throughput

0.407

High

1291679

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

8

High-throughput

0.407

High

1294827

STX12
Syntaxin-12

1

10

High-throughput

0.407

High

1307972

EPHX4
Epoxide hydrolase 4

1

1

High-throughput

0.407

High

1311234

SGPP2
Sphingosine-1-phosphate phosphatase 2

1

1

High-throughput

0.407

High

1313226

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

3

High-throughput

0.407

High

1322587

CP4X1
Cytochrome P450 4X1

1

3

High-throughput

0.407

High

1324309

GHDC
GH3 domain-containing protein

1

3

High-throughput

0.407

High

1328625

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

2

High-throughput

0.407

High

1333986

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.407

High

1334320

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

2

High-throughput

0.407

High

1335816

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

20

High-throughput

0.407

High

1337001

DIK2A
Divergent protein kinase domain 2A

1

5

High-throughput

0.407

High

1339458

TOIP2
Torsin-1A-interacting protein 2

1

4

High-throughput

0.407

High

1348312

GOGA5
Golgin subfamily A member 5

1

15

High-throughput

0.407

High

1362082

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

14

High-throughput

0.407

High

1364087

SNX19
Sorting nexin-19

1

5

High-throughput

0.407

High

1395589

FACR2
Fatty acyl-CoA reductase 2

1

5

High-throughput

0.407

High

1402821

TM209
Transmembrane protein 209

1

1

High-throughput

0.407

High

1404189

SEC62
Translocation protein SEC62

1

4

High-throughput

0.407

High

1408224

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

19

High-throughput

0.407

High

1409706

MICU1
Calcium uptake protein 1, mitochondrial

1

2

High-throughput

0.407

High

1411627

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

4

High-throughput

0.407

High

1412576

CQ080
Mitochondrial nucleoid-associated protein 1

1

3

High-throughput

0.407

High

1415763

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

2

High-throughput

0.407

High

1421350

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

1

High-throughput

0.407

High

1421351

SNX25
Sorting nexin-25

1

8

High-throughput

0.407

High

1421352

PGES2
Prostaglandin E synthase 2

1

1

High-throughput

0.407

High

1421353

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

5

High-throughput

0.407

High

1421354

FKRP
Ribitol 5-phosphate transferase FKRP

1

3

High-throughput

0.407

High

1421356

AT131
Endoplasmic reticulum transmembrane helix translocase

1

3

High-throughput

0.407

High

1421357

VPS45
Vacuolar protein sorting-associated protein 45

1

6

High-throughput

0.407

High

1421358

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

13

High-throughput

0.407

High

1421360

MDN1
Midasin

1

3

High-throughput

0.407

High

1421362

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.407

High

1421365

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.407

High

1421366

OCAD1
OCIA domain-containing protein 1

1

3

High-throughput

0.407

High

1421367

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

5

High-throughput

0.407

High

1421368

CHPF2
Chondroitin sulfate glucuronyltransferase

1

20

High-throughput

0.407

High

1421371

DJC12
DnaJ homolog subfamily C member 12

1

5

High-throughput

0.407

High

1421376

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.407

High

1421377

PXMP4
Peroxisomal membrane protein 4

1

2

High-throughput

0.407

High

1351783

ST7L
Suppressor of tumorigenicity 7 protein-like

2

0

High-throughput

0.328

High

70989

CEBOS
Protein CEBPZOS

1

0

High-throughput

0.232

Low

223754

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.232

Low

430642

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.232

Low

884474

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

High-throughput

0.232

Low

1013449

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.232

Low

1112453

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.232

Low

1257992

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.232

Low

1357945

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.232

Low

1406289

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.232

Low

1416208

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.232

Low

1421363

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.232

Low

1421370

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025