HitPredict

Interactor 1: Q9JHK1 (Q9JHK1)
Caspase-9
Gene: Casp9

Interactor 2: XIAP (Q9R0I6)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27052476
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~zf-C3HC4_3, BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0032991 - protein-containing complex GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Rn			1 496
+	Hs
		876972 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		XIAP_HUMAN (1-496): 0: 582: 89.54
+	Hs
		957707 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		XIAP_HUMAN (1-496): 0: 582: 89.54
+	Mm
		140032 CASP9_MOUSE (1-454): 0: 527: 90.97		BIRC3_MOUSE (3-496): 4.88e-81: 265: 24.71
+	Hs
		876980 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC3_HUMAN (3-496): 9.22e-72: 240: 22.74
+	Hs
		1035745 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		BIRC3_HUMAN (3-496): 9.22e-72: 240: 22.74
+	Hs
		667461 CASP1_HUMAN (1-451): 1.27e-116: 349: 21.17		BIRC3_HUMAN (3-496): 9.22e-72: 240: 22.74
+	Hs
		876997 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC7_HUMAN (16-152): 7.05e-32: 125: 21.74
+	Hs
		876987 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		Q6PIA0_HUMAN (160-263): 1.22e-30: 120: 30.48
+	Hs
		876998 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC8_HUMAN (160-263): 1.85e-30: 120: 30.48
+	Hs
		877004 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC6_HUMAN (254-441): 7.08e-26: 114: 18.50
+	Hs
		876977 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC1_HUMAN (3-103): 2.37e-24: 109: 35.64
+	Hs
		876981 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC2_HUMAN (404-496): 1.49e-23: 106: 39.79
+	Hs
		876995 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		RNF34_HUMAN (428-496): 1.59e-19: 92.2: 34.78
+	Hs
		177664 CASP9_HUMAN (1-454): 1.16e-150: 436: 71.59		BIRC5_HUMAN (265-368): 1.67e-20: 89.6: 29.73
+	Hs
		1059377 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		BIRC6_HUMAN (254-441): 7.08e-26: 114: 18.50
+	Hs
		1059332 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		RFFL_HUMAN (324-496): 7.73e-26: 110: 20.23
+	Hs
		788252 CASP2_HUMAN (1-453): 5.24e-120: 359: 27.68		BIRC2_HUMAN (404-496): 1.49e-23: 106: 39.79
+	Hs
		1036271 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		BIRC2_HUMAN (404-496): 1.49e-23: 106: 39.79
+	Hs
		1059336 CASP8_HUMAN (3-453): 4.75e-118: 355: 24.90		RNF34_HUMAN (428-496): 1.59e-19: 92.2: 34.78
+	Dm
		1097069 DRONC_DROME (1-453): 5.11e-102: 313: 23.64		DIAP1_DROME (240-348): 4.03e-17: 85.4: 28.18