HitPredict

Interactor 1: PCD12 (Q9NPG4)
Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form]
Gene: PCDH12

Interactor 2: CELR1 (Q9NYQ6)
Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)
Gene: CELSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1184 Hs			1 3014
+	Hs
		1336506 PCD12_HUMAN (26-1184): 0: 1280: 100.00		CELR2_HUMAN (1-557): 3.48e-96: 351: 20.11
+	Hs
		1378035 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG4_HUMAN (1-557): 5.94e-110: 378: 19.48
+	Hs
		1378037 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG4_HUMAN (1-557): 5.94e-110: 378: 19.48
+	Hs
		1378023 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG9_HUMAN (1-575): 1.01e-108: 374: 18.89
+	Hs
		231362 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG4_HUMAN (1-557): 5.94e-110: 378: 19.48
+	Hs
		231360 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG9_HUMAN (1-575): 1.01e-108: 374: 18.89
+	Hs
		1295693 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCD16_HUMAN (1-556): 7.07e-98: 357: 18.75
+	Hs
		1377978 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDB3_HUMAN (1-557): 1.05e-99: 343: 17.80
+	Hs
		1378030 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG7_HUMAN (11-452): 1.42e-71: 263: 18.72
+	Hs
		1378031 PCDG5_HUMAN (2-918): 0: 818: 27.87		PCDG7_HUMAN (11-452): 1.42e-71: 263: 18.72
+	Hs
		231361 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDG7_HUMAN (11-452): 1.42e-71: 263: 18.72
+	Hs
		1378034 PCDG6_HUMAN (2-834): 0: 824: 30.09		PCDG5_HUMAN (932-1184): 1.31e-35: 150: 25.91
+	Hs
		1350276 PCD10_HUMAN (18-786): 0: 812: 35.15		PCDGD_HUMAN (245-679): 2.62e-33: 143: 26.89
+	Hs
		231359 PCDGC_HUMAN (25-918): 0: 812: 28.76		PCDGD_HUMAN (245-679): 2.62e-33: 143: 26.89
+	Hs
		1295692 PCDG7_HUMAN (1-557): 5.39e-125: 409: 24.66		PCD16_HUMAN (1-556): 7.07e-98: 357: 18.75
+	Hs
		1377980 PCDC2_HUMAN (32-707): 3.36e-126: 414: 38.21		PCDB3_HUMAN (1-557): 1.05e-99: 343: 17.80
+	Hs
		1250859 PCD19_HUMAN (25-752): 2.77e-140: 456: 37.84		PCDGD_HUMAN (245-679): 2.62e-33: 143: 26.89
+	Hs
		1378019 PCDG7_HUMAN (1-557): 5.39e-125: 409: 24.66		PCDGD_HUMAN (245-679): 2.62e-33: 143: 26.89