HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.981

Property	Details
Experiments	29997244, 31253590, 33961781, 21145461, 23098073, 28514442, 28883622, 30833792, 26264872, 21980433, 23897481, 32814053
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, pull down, proximity labelling technology, x-ray crystallography, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 780
+	Mm
		193366 SOCS2_MOUSE (1-198): 3.15e-63: 196: 93.94		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146692 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1257617 SOCS7_MOUSE (31-196): 2.38e-49: 170: 32.18		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147440 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		256856 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1143676 CISH_MOUSE (3-198): 1.55e-47: 157: 37.56		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146625 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Mm
		193394 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1274062 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		147544 SOCS6_HUMAN (2-196): 4.82e-41: 147: 31.03		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		222648 SOCS5_MOUSE (11-197): 1.09e-42: 151: 29.63		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1263831 SOCS4_HUMAN (14-197): 9.03e-41: 144: 27.96		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1265273 SOCS4_MOUSE (13-197): 8.66e-42: 147: 27.81		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1322060 SOCS6_MOUSE (2-196): 1.63e-40: 145: 31.03		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		411713 LCK_HUMAN (1-172): 3.23e-43: 152: 15.63		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		337467 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		789064 ABL2_HUMAN (3-173): 3.14e-42: 152: 18.50		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		147421 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		337468 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041477 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL2_HUMAN (6-780): 0: 699: 26.36