HitPredict

Interactor 1: ACKR2 (O00590)
Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)
Gene: ACKR2

Interactor 2: CCL3 (P10147)
C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Gene: CCL3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9405404
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0019722 - calcium-mediated signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 384 Hs			1 92
+	Hs
		486237 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00
+	Hs
		561732 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62
+	Hs
		526564 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61
+	Hs
		849619 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71
+	Hs
		849616 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL14_HUMAN (1-91): 1.29e-32: 110: 47.31
+	Hs
		849613 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL18_HUMAN (1-92): 4.05e-29: 101: 59.78
+	Hs
		528252 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL5_HUMAN (1-91): 2.5e-28: 99.3: 49.45
+	Hs
		849617 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL15_HUMAN (1-89): 7.95e-28: 98.9: 41.28
+	Hs
		849614 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL7_HUMAN (17-92): 2.89e-27: 97: 31.17
+	Hs
		118813 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL24_HUMAN (1-91): 1.9e-26: 95.4: 33.70
+	Hs
		849504 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL11_HUMAN (1-92): 4.85e-26: 93.9: 38.71
+	Hs
		528210 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL2_HUMAN (1-92): 6.89e-26: 93.5: 36.17
+	Hs
		486231 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00
+	Hs
		849620 CCR3_HUMAN (20-360): 6.39e-99: 299: 36.71		CCL26_HUMAN (21-89): 2.08e-24: 89.6: 40.58
+	Hs
		526561 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61
+	Hs
		528245 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL5_HUMAN (1-91): 2.5e-28: 99.3: 49.45
+	Hs
		802290 XCR1_HUMAN (11-342): 2.52e-90: 276: 34.94		XCL1_HUMAN (1-92): 2.8e-23: 87.3: 31.52
+	Hs
		180159 CXCR5_HUMAN (25-354): 3.22e-88: 272: 31.11		CCL16_HUMAN (1-90): 2.08e-24: 90.4: 36.17
+	Mm
		500591 CCR3_MOUSE (33-360): 3.49e-79: 249: 35.44		CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19
+	Mm
		534669 CCR3_MOUSE (33-360): 3.49e-79: 249: 35.44		CCL4_MOUSE (1-91): 8.69e-29: 100: 57.61