Protein: RPOM
DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)

Gene: RPOM, POLRMT
Organism: Homo sapiens
Interactions: 225
UniProt ID: O00411

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0001018 - mitochondrial promoter sequence-specific DNA binding
GO:0003723 - RNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

134382

TFB2M
Dimethyladenosine transferase 2, mitochondrial

2

1

Small-scale

0.754

High

134343

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

3

Small-scale

0.724

High

134269

RM12
Large ribosomal subunit protein bL12m

4

0

Small-scale

0.667

High

134241

IKBA
NF-kappa-B inhibitor alpha

5

1

Small-scale

0.652

High

134336

KCD17
BTB/POZ domain-containing protein KCTD17

4

2

High-throughput

0.630

High

134325

DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

2

0

High-throughput

0.602

High

134299

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

134361

TEFM
Transcription elongation factor, mitochondrial

2

0

Small-scale

0.585

High

134348

NELL1
Protein kinase C-binding protein NELL1

2

3

High-throughput

0.574

High

134354

VWCE
von Willebrand factor C and EGF domain-containing protein

2

4

High-throughput

0.574

High

134364

NELL2
Protein kinase C-binding protein NELL2

2

3

High-throughput

0.574

High

134220

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

134291

GRB10
Growth factor receptor-bound protein 10

2

1

High-throughput

0.571

High

134206

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

134287

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

134306

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

134278

TFAM
Transcription factor A, mitochondrial

2

0

Small-scale

0.547

High

134208

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

1

High-throughput

0.536

High

134210

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.536

High

134260

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

134274

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.536

High

134417

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.536

High

134202

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

1

High-throughput

0.521

High

134230

FGFR1
Fibroblast growth factor receptor 1

2

1

High-throughput

0.521

High

134258

KPCI
Protein kinase C iota type

2

1

High-throughput

0.521

High

134284

KPCZ
Protein kinase C zeta type

2

1

High-throughput

0.521

High

134199

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.513

High

134211

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

134222

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

134224

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

134232

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.513

High

134243

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

134244

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

134245

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

134248

GRN
Progranulin

1

0

High-throughput

0.513

High

134254

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

134266

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

134268

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

134276

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.513

High

134304

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

134320

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

134330

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

134357

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

134385

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

134391

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

134406

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

134407

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

134415

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

134416

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

134419

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

134251

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

134338

KCTD6
BTB/POZ domain-containing protein KCTD6

1

1

High-throughput

0.489

High

134359

HIPL1
HHIP-like protein 1

1

1

High-throughput

0.489

High

134390

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.489

High

134401

FBLN5
Fibulin-5

1

1

High-throughput

0.489

High

134412

SRPK3
SRSF protein kinase 3

1

2

High-throughput

0.489

High

134414

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

134228

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

134207

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

134209

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

134217

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

134221

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

134262

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

134286

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

134315

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

134317

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

1

Small-scale

0.479

High

134326

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

134346

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

134350

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

134378

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

134386

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

134395

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

134404

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

66078

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

128601

MEN1
Menin

1

0

High-throughput

0.458

High

134200

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

134204

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

134213

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

134218

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

134219

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

134225

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

134226

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

134227

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

134229

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

134231

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

134236

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

134240

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

134257

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

134259

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

134261

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

134265

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

134273

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

134283

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

134285

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

134288

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

134289

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

134290

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

134292

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

134293

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

134294

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

134297

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

134305

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

134307

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

134309

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

134311

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

134323

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

134324

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

134329

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

134332

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

134342

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

134345

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

134349

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

134351

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

134353

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

134355

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

134356

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

134362

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

134363

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

134367

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.458

High

134369

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

134370

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

134371

TR61B
tRNA

1

0

High-throughput

0.458

High

134373

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

134375

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

134376

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

134377

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

134380

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

134383

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

134384

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

134387

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

0

Small-scale

0.458

High

134392

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

134393

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

134397

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

134398

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

134418

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

134421

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

134301

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

Small-scale

0.445

High

134215

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

134271

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

134272

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

134277

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

134279

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.437

High

134331

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.437

High

134334

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

134337

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.437

High

134379

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.437

High

134389

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.437

High

134410

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

134203

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

134223

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

134235

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

134256

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

134263

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.426

High

134270

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.426

High

134275

PRR3
Proline-rich protein 3

1

0

High-throughput

0.426

High

134295

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.426

High

134302

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.426

High

134312

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

134319

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

134341

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.426

High

134368

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

134394

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

134396

GRHL1
Grainyhead-like protein 1 homolog

1

0

High-throughput

0.426

High

134255

TNR3
Tumor necrosis factor receptor superfamily member 3

3

0

High-throughput

0.347

High

134402

TRI10
Tripartite motif-containing protein 10

3

0

High-throughput

0.347

High

134413

CLC11
C-type lectin domain family 11 member A

3

0

High-throughput

0.347

High

134205

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

0

High-throughput

0.328

High

134403

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

134296

CUL3
Cullin-3

2

0

High-throughput

0.318

High

134201

MAGB2
Melanoma-associated antigen B2

2

0

High-throughput

0.313

High

134409

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.313

High

134388

ANLN
Anillin

2

0

High-throughput

0.305

High

134405

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.305

High

134214

HEXI1
Protein HEXIM1

2

0

High-throughput

0.298

High

134237

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.298

High

134238

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

0

High-throughput

0.279

Low

134242

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

134249

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

134264

NEST
Nestin

1

0

High-throughput

0.279

Low

134280

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

0

High-throughput

0.279

Low

134282

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.279

Low

134298

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

134300

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

134308

KLH22
Kelch-like protein 22

1

0

High-throughput

0.279

Low

134313

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.279

Low

134314

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

134316

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

134321

ZN574
Zinc finger protein 574

1

0

High-throughput

0.279

Low

134328

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

134344

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.279

Low

134360

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

134365

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

High-throughput

0.279

Low

134366

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.279

Low

134372

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.279

Low

134374

FOXQ1
Forkhead box protein Q1

1

0

High-throughput

0.279

Low

134400

RNF14
E3 ubiquitin-protein ligase RNF14

1

0

High-throughput

0.279

Low

134250

ERP29
Endoplasmic reticulum resident protein 29

1

0

High-throughput

0.269

Low

134212

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

134216

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

134233

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

134234

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

134246

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

134247

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.249

Low

134252

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.249

Low

134253

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

134267

EMD
Emerin

1

0

High-throughput

0.249

Low

134303

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

134318

ZN746
Zinc finger protein 746

1

0

High-throughput

0.249

Low

134322

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

134327

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

134339

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

134340

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

134347

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.249

Low

134352

PF21A
PHD finger protein 21A

1

0

High-throughput

0.249

Low

134358

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

134381

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

134399

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

134408

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

134411

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.249

Low

134239

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

0

High-throughput

0.232

Low

134281

H11
Histone H1.1

1

0

High-throughput

0.232

Low

134310

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.232

Low

134333

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.232

Low

134335

RNF10
E3 ubiquitin-protein ligase RNF10

1

0

High-throughput

0.232

Low

134420

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025