HitPredict

Interactor 1: PPP6 (O00743)
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
Gene: PPP6C

Interactor 2: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	35842423, 19955178, 17079228
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, phosphatase assay, anti bait coimmunoprecipitation
Interaction Type	physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 606
+	Hs
		201297 PP2AA_HUMAN (5-305): 0: 531: 58.14		M3K7_HUMAN (1-606): 0: 574: 100.00
+	Mm
		1143270 PPP6_MOUSE (1-305): 0: 529: 99.67		M3K7_MOUSE (1-606): 0: 545: 94.88
+	Hs
		905847 PP1A_HUMAN (4-292): 0: 517: 42.28		FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04
+	Mm
		710129 PP1A_MOUSE (4-292): 0: 517: 41.95		FAK1_MOUSE (30-603): 3.08e-120: 383: 21.49
+	Mm
		930629 PP2AA_MOUSE (5-305): 0: 530: 58.14		EPHA5_MOUSE (16-325): 1.09e-100: 327: 27.66
+	At
		984290 PP2A1_ARATH (5-305): 0: 520: 58.80		CTR1_ARATH (30-290): 1.34e-102: 331: 31.85
+	Hs
		738149 PP1G_HUMAN (1-302): 0: 520: 40.84		RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29