HitPredict

Interactor 1: PPP6 (O00743)
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
Gene: PPP6C

Interactor 2: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29467282, 17314511
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 305 Hs			1 454
+	Hs
		346475 PP2AA_HUMAN (5-305): 0: 531: 58.14		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346104 PP1G_HUMAN (1-302): 0: 520: 40.84		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		346409 PP1A_HUMAN (4-292): 0: 517: 42.28		MYC_HUMAN (1-454): 1.73e-122: 366: 100.00
+	Hs
		379204 PP1A_HUMAN (4-292): 0: 517: 42.28		MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40
+	Hs
		607790 PP1G_HUMAN (1-302): 0: 520: 40.84		USF1_HUMAN (175-453): 1.02e-39: 146: 18.40
+	Hs
		898094 PP2AB_HUMAN (5-305): 0: 531: 58.80		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67
+	Hs
		898097 PP2AA_HUMAN (5-305): 0: 531: 58.14		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67
+	Mm
		659347 PP1G_MOUSE (1-302): 0: 519: 40.84		MAX_MOUSE (354-454): 3.52e-25: 102: 32.67
+	Hs
		737681 PP1G_HUMAN (1-302): 0: 520: 40.84		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67
+	Mm
		659345 PP1A_MOUSE (4-292): 0: 517: 41.95		MAX_MOUSE (354-454): 3.52e-25: 102: 32.67
+	Hs
		898092 PP1A_HUMAN (4-292): 0: 517: 42.28		MAX_HUMAN (354-454): 1.39e-24: 101: 32.67