HitPredict

Interactor 1: IF2B3 (O00425)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Gene: IGF2BP3

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Hs			1 2581
+	Hs
		1439223 IF2B1_HUMAN (1-579): 7.39e-139: 417: 72.02		CHD8_HUMAN (1-2581): 0: 2337: 100.00
+	Hs
		1439243 IF2B2_HUMAN (79-488): 3.33e-19: 93.5: 15.13		CHD8_HUMAN (1-2581): 0: 2337: 100.00
+	Hs
		550477 PABP1_HUMAN (74-346): 2.48e-13: 75: 8.80		CHD8_HUMAN (1-2581): 0: 2337: 100.00
+	Hs
		135190 IF2B3_HUMAN (1-579): 5.25e-152: 450: 100.00		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1088593 IF2B1_HUMAN (1-579): 7.39e-139: 417: 72.02		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1133013 IF2B1_HUMAN (1-579): 7.39e-139: 417: 72.02		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Dm
		356927 Q9VZ69_DROME (171-572): 3.86e-84: 274: 41.05		CHDM_DROME (494-2066): 0: 996: 22.98
+	Hs
		1088358 PCBP1_HUMAN (277-508): 3.87e-32: 129: 24.14		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1088495 FUBP1_HUMAN (353-559): 3.07e-30: 127: 23.22		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1088359 PCBP2_HUMAN (277-508): 7.6e-31: 125: 24.14		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1132709 PCBP2_HUMAN (277-508): 7.6e-31: 125: 24.14		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		1088645 IF2B2_HUMAN (79-488): 3.33e-19: 93.5: 15.13		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1088320 PABP4_HUMAN (73-346): 1.09e-15: 82.3: 8.07		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		550249 PABP1_HUMAN (74-346): 2.48e-13: 75: 8.80		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		965645 HNRPK_HUMAN (154-266): 6.19e-09: 60.6: 21.24		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1101959 PABP4_HUMAN (73-346): 1.09e-15: 82.3: 8.07		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		550289 PABP1_HUMAN (74-346): 2.48e-13: 75: 8.80		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		965676 HNRPK_HUMAN (154-266): 6.19e-09: 60.6: 21.24		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		1101977 PABP4_HUMAN (73-346): 1.09e-15: 82.3: 8.07		CHD9_HUMAN (2104-2481): 3.9e-107: 387: 29.62
+	Hs
		550308 PABP1_HUMAN (74-346): 2.48e-13: 75: 8.80		CHD9_HUMAN (2104-2481): 3.9e-107: 387: 29.62