HitPredict

Interactor 1: Q9U2T9 (Q9U2T9)
Intersectin-1
Gene: itsn-1

Interactor 2: PICAL (Q9XZI6)
Phosphatidylinositol-binding clathrin assembly protein unc-11 (AP180-like adaptor protein) (Uncoordinated protein 11)
Gene: unc-11

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.668

Property	Details
Experiments	19123269, 18298590, 23549480
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042734 - presynaptic membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1085 Ce			1 586
+	Hs
		787907 EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12		PICAL_HUMAN (16-584): 1.01e-129: 396: 35.34
+	Hs
		237877 EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12		AP180_HUMAN (16-516): 7.88e-94: 309: 41.09
+	Hs
		1036409 ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35		PICAL_HUMAN (16-584): 1.01e-129: 396: 35.34
+	Hs
		787913 EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12		EPN4_HUMAN (27-586): 1.1e-63: 222: 14.88
+	Hs
		124413 ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35		HIP1_HUMAN (1-350): 1.8e-98: 324: 13.19
+	Sc
		710396 EDE1_YEAST (171-297): 9.84e-10: 65: 22.05		AP18B_YEAST (34-533): 7.31e-96: 305: 22.10
+	Hs
		557693 NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27		EPN4_HUMAN (27-586): 1.1e-63: 222: 14.88
+	Ce
		711199 YKA7_CAEEL (665-936): 1.1e-19: 95.9: 16.61		SLAP2_CAEEL (27-363): 3.89e-71: 247: 12.47
+	Sc
		704769 EDE1_YEAST (171-297): 9.84e-10: 65: 22.05		SLA2_YEAST (34-385): 5.61e-63: 225: 18.28