Protein: GIPC1
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)

Gene: GIPC1
Organism: Homo sapiens
Interactions: 132
UniProt ID: O14908

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005102 - signaling receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005938 - cell cortex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167658

ARHGC
Rho guanine nucleotide exchange factor 12

5

4

High-throughput

0.935

High

167659

SH3B4
SH3 domain-binding protein 4

4

1

Small-scale

0.913

High

167625

DP13B
DCC-interacting protein 13-beta

2

5

High-throughput

0.789

High

167628

GIPC2
PDZ domain-containing protein GIPC2

2

4

High-throughput

0.789

High

167664

DP13A
DCC-interacting protein 13-alpha

2

3

High-throughput

0.789

High

167665

MYO6
Unconventional myosin-VI

7

5

Small-scale

0.745

High

167601

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

2

High-throughput

0.665

High

167591

LRP2
Low-density lipoprotein receptor-related protein 2

3

3

Small-scale

0.658

High

167652

PKHA2
Pleckstrin homology domain-containing family A member 2

3

4

High-throughput

0.653

High

167583

RGS19
Regulator of G-protein signaling 19

2

3

Small-scale

0.629

High

167627

GIPC3
PDZ domain-containing protein GIPC3

1

4

High-throughput

0.618

High

167646

SEM4C
Semaphorin-4C

2

5

High-throughput

0.611

High

167571

ITA6
Integrin alpha-6

2

1

Small-scale

0.606

High

167543

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

0

High-throughput

0.586

High

167568

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.586

High

167589

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.586

High

167616

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.586

High

167637

SNX27
Sorting nexin-27

1

0

High-throughput

0.586

High

167663

GULP1
PTB domain-containing engulfment adapter protein 1

1

0

High-throughput

0.586

High

167645

DOCK9
Dedicator of cytokinesis protein 9

2

0

High-throughput

0.585

High

164173

NRP1
Neuropilin-1

2

1

Small-scale

0.584

High

167553

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

167609

PKHG6
Pleckstrin homology domain-containing family G member 6

2

5

High-throughput

0.571

High

167544

KIF1B
Kinesin-like protein KIF1B

1

2

Small-scale

0.561

High

167562

ACTN1
Alpha-actinin-1

1

1

Small-scale

0.561

High

167632

LPAR1
Lysophosphatidic acid receptor 1

1

2

Small-scale

0.561

High

167542

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

167565

TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase

1

0

Small-scale

0.558

High

167643

CAR10
Caspase recruitment domain-containing protein 10

1

0

High-throughput

0.557

High

167557

ADRB1
Beta-1 adrenergic receptor

1

1

Small-scale

0.552

High

167570

LSHR
Lutropin-choriogonadotropic hormone receptor

1

0

Small-scale

0.549

High

167660

KLHL9
Kelch-like protein 9

1

2

High-throughput

0.536

High

167661

KLH13
Kelch-like protein 13

1

2

High-throughput

0.536

High

167558

ITA5
Integrin alpha-5

1

1

Small-scale

0.527

High

167598

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

3

Small-scale

0.527

High

123503

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.515

High

167582

RXRG
Retinoic acid receptor RXR-gamma

1

3

High-throughput

0.515

High

167619

SDCG8
Serologically defined colon cancer antigen 8

1

1

High-throughput

0.515

High

167630

RFFL
E3 ubiquitin-protein ligase rififylin

1

1

High-throughput

0.515

High

167634

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

High-throughput

0.515

High

167644

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

1

High-throughput

0.515

High

167667

KLH20
Kelch-like protein 20

1

2

High-throughput

0.515

High

167575

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.513

High

167595

TGBR3
Transforming growth factor beta receptor type 3

1

1

Small-scale

0.506

High

167560

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

Small-scale

0.504

High

167653

LPAR2
Lysophosphatidic acid receptor 2

1

2

Small-scale

0.501

High

167573

SDC4
Syndecan-4

1

0

Small-scale

0.493

High

167574

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.493

High

167586

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

167587

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.493

High

167593

TAGL
Transgelin

1

0

High-throughput

0.493

High

167615

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.493

High

167622

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.493

High

167639

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.493

High

167540

TELT
Telethonin

1

0

High-throughput

0.493

High

167606

MK11
Mitogen-activated protein kinase 11

1

0

High-throughput

0.493

High

167608

SGSM1
Small G protein signaling modulator 1

1

0

High-throughput

0.493

High

167611

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.493

High

167613

FAP20
Fanconi anemia core complex-associated protein 20

1

0

High-throughput

0.493

High

167618

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.493

High

167623

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

167624

ACBD4
Acyl-CoA-binding domain-containing protein 4

1

0

High-throughput

0.493

High

167636

F163A
Protein FAM163A

1

0

High-throughput

0.493

High

167651

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

0

High-throughput

0.493

High

167654

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.493

High

167666

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.493

High

167578

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.486

High

167584

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

167576

DRD3
D(3) dopamine receptor

1

1

Small-scale

0.481

High

167602

LRP8
Low-density lipoprotein receptor-related protein 8

1

3

Small-scale

0.481

High

167541

STRN
Striatin

1

3

High-throughput

0.479

High

167546

TOM1
Target of Myb1 membrane trafficking protein

1

1

High-throughput

0.479

High

167550

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

167566

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

167577

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.479

High

167592

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

167599

STRN3
Striatin-3

1

3

High-throughput

0.479

High

167604

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

167607

NTRK2
BDNF/NT-3 growth factors receptor

1

4

Small-scale

0.479

High

167617

TM1L2
TOM1-like protein 2

1

1

High-throughput

0.479

High

167641

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.479

High

167648

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

167657

STRN4
Striatin-4

1

3

High-throughput

0.479

High

167668

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

167569

CO9A1

1

1

High-throughput

0.470

High

167545

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

167556

PROF1
Profilin-1

1

0

High-throughput

0.458

High

167559

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

167561

BCR
Breakpoint cluster region protein

1

0

Small-scale

0.458

High

167563

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

167564

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.458

High

167572

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

0

High-throughput

0.458

High

167579

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

167585

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.458

High

167590

H31
Histone H3.1

1

0

High-throughput

0.458

High

167594

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

High-throughput

0.458

High

167603

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

167605

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.458

High

167610

FBP1L
Formin-binding protein 1-like

1

0

High-throughput

0.458

High

167620

FMNL3
Formin-like protein 3

1

0

High-throughput

0.458

High

167631

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

167638

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.458

High

167647

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

167649

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

Small-scale

0.458

High

167656

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

167662

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

167669

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.458

High

167612

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

167552

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

167554

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

167555

NTRK1
High affinity nerve growth factor receptor

1

4

Small-scale

0.437

High

167567

EGLN
Endoglin

1

1

Small-scale

0.437

High

167633

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

167642

OVOL2
Transcription factor Ovo-like 2

1

1

Small-scale

0.437

High

167600

TPBG
Trophoblast glycoprotein

1

0

Small-scale

0.288

High

167581

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

0

High-throughput

0.282

High

167640

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.279

Low

167655

C1QR1
Complement component C1q receptor

1

0

Small-scale

0.275

Low

167547

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

0

High-throughput

0.268

Low

167549

STX11
Syntaxin-11

1

0

High-throughput

0.268

Low

167588

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.268

Low

167597

GABP1
GA-binding protein subunit beta-1

1

0

High-throughput

0.268

Low

167614

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

167621

ZN444
Zinc finger protein 444

1

0

High-throughput

0.268

Low

167626

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.268

Low

167629

ZN296
Zinc finger protein 296

1

0

High-throughput

0.268

Low

167635

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.268

Low

167650

ZN408
Zinc finger protein 408

1

0

High-throughput

0.265

Low

167548

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

167580

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.249

Low

167596

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

0

High-throughput

0.249

Low

167551

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025