Protein: TPA
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]

Gene: TPA, PLAT
Organism: Homo sapiens
Interactions: 53
UniProt ID: P00750

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341525

PAI2
Plasminogen activator inhibitor 2

2

20

High-throughput

0.811

High

341528

IC1
Plasma protease C1 inhibitor

2

20

High-throughput

0.811

High

341545

SPB6
Serpin B6

2

20

High-throughput

0.811

High

341564

ZPI
Protein Z-dependent protease inhibitor

2

20

High-throughput

0.811

High

341521

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

5

Small-scale

0.778

High

341526

PAI1
Plasminogen activator inhibitor 1

2

20

Small-scale

0.778

High

341549

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

11

Small-scale

0.696

High

341558

NEUS
Neuroserpin

1

20

Small-scale

0.692

High

341531

HEPS
Serine protease hepsin

1

11

High-throughput

0.691

High

341536

A2AP
Alpha-2-antiplasmin

1

20

High-throughput

0.691

High

341546

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.691

High

341548

NOTC2
Neurogenic locus notch homolog protein 2

1

10

High-throughput

0.691

High

341559

TMPSD
Transmembrane protease serine 13

1

15

High-throughput

0.691

High

341565

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

341550

FGL1
Fibrinogen-like protein 1

3

5

High-throughput

0.667

High

341532

GDN
Glia-derived nexin

1

20

High-throughput

0.665

High

341300

FA10
Coagulation factor X

1

15

Small-scale

0.647

High

341475

UROK
Urokinase-type plasminogen activator

1

16

Small-scale

0.647

High

341518

TPA
Tissue-type plasminogen activator

1

15

Small-scale

0.647

High

341522

FINC
Fibronectin

1

11

Small-scale

0.647

High

341524

A4
Amyloid-beta precursor protein

1

18

Small-scale

0.647

High

341527

IPSP
Plasma serine protease inhibitor

1

20

Small-scale

0.647

High

341529

TETN
Tetranectin

1

3

Small-scale

0.647

High

341553

LAMA3
Laminin subunit alpha-3

1

15

Small-scale

0.647

High

341560

PDGFC
Platelet-derived growth factor C

1

17

Small-scale

0.647

High

341557

TMM25
Transmembrane protein 25

3

0

High-throughput

0.638

High

341537

IBP1
Insulin-like growth factor-binding protein 1

2

6

High-throughput

0.628

High

341534

PGS2
Decorin

1

6

High-throughput

0.618

High

180673

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

341547

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

341520

IFN14
Interferon alpha-14

2

0

High-throughput

0.585

High

341116

THRB
Prothrombin

1

15

Small-scale

0.575

High

341535

MSMB
Beta-microseminoprotein

1

1

High-throughput

0.536

High

341539

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.536

High

341540

CL3L1
C-C motif chemokine 3-like 1

1

1

High-throughput

0.536

High

341544

CALX
Calnexin

1

8

High-throughput

0.536

High

341563

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

341556

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.513

High

341530

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.501

High

341533

ANXA2
Annexin A2

1

1

Small-scale

0.501

High

341541

VDAC1
Voltage-dependent anion-selective channel protein 1

1

9

Small-scale

0.501

High

341542

LAMA1
Laminin subunit alpha-1

1

12

Small-scale

0.501

High

341543

CALR
Calreticulin

1

8

Small-scale

0.501

High

341519

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

341551

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

8

High-throughput

0.479

High

341554

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

341561

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

341538

HMGB1
High mobility group protein B1

1

5

Small-scale

0.445

High

341523

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.437

High

341555

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

341562

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.437

High

341552

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024