HitPredict

Interactor 1: RABX5 (Q9UJ41)
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
Gene: RABGEF1

Interactor 2: RAB21 (Q9UL25)
Ras-related protein Rab-21
Gene: RAB21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.875

Property	Details
Experiments	28514442, 33961781, 17450153
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Ras~VPS9
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 491 Hs			1 225
+	Hs
		914438 RABX5_HUMAN (1-491): 0: 563: 100.00		RB11A_HUMAN (9-224): 6.96e-85: 252: 32.41
+	Hs
		844787 RABX5_HUMAN (1-491): 0: 563: 100.00		RAB5C_HUMAN (1-224): 1.01e-51: 168: 39.82
+	Hs
		592565 RABX5_HUMAN (1-491): 0: 563: 100.00		RAB5A_HUMAN (10-224): 2.26e-49: 162: 41.28
+	Hs
		1355935 RABX5_HUMAN (1-491): 0: 563: 100.00		RB22A_HUMAN (20-203): 8.19e-45: 149: 44.62
+	Dm
		1358752 Q9W0H9_DROME (1-470): 4.91e-143: 428: 33.27		RAB5_DROME (6-203): 4.32e-47: 156: 41.75
+	Mm
		722766 ANR27_MOUSE (123-435): 3.16e-77: 263: 17.90		RAB21_MOUSE (18-225): 1.13e-107: 310: 97.60
+	Ce
		954788 Q8I100_CAEEL (4-476): 3.7e-125: 376: 29.88		P91857_CAEEL (1-180): 8.48e-49: 160: 42.78
+	Hs
		1298922 ANR27_HUMAN (123-435): 9.66e-78: 264: 18.83		RAB21_HUMAN (1-225): 8.99e-90: 265: 100.00
+	Hs
		1137131 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		Q5U0I6_HUMAN (9-222): 6.14e-87: 257: 32.24
+	Hs
		918912 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		RAB1A_HUMAN (9-222): 6.14e-87: 257: 32.24
+	Hs
		72912 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		B4DMN1_HUMAN (8-224): 1.88e-85: 255: 32.26
+	Sc
		731194 VPS9_YEAST (119-482): 2.98e-86: 274: 23.89		VPS21_YEAST (19-223): 1.91e-42: 144: 38.46
+	Hs
		844638 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		RAB5C_HUMAN (1-224): 1.01e-51: 168: 39.82
+	Hs
		592390 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		RAB5A_HUMAN (10-224): 2.26e-49: 162: 41.28
+	Hs
		895368 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		RAB5B_HUMAN (10-224): 8.75e-47: 155: 38.61
+	Ce
		954790 RME6_CAEEL (40-369): 8.48e-70: 242: 21.66		P91857_CAEEL (1-180): 8.48e-49: 160: 42.78
+	Hs
		1044482 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		RAB31_HUMAN (20-196): 6.55e-46: 152: 44.63
+	Hs
		1120221 RIN3_HUMAN (62-454): 1.24e-71: 247: 18.10		Q53EY4_HUMAN (20-196): 6.55e-46: 152: 44.63
+	Hs
		592407 RIN2_HUMAN (140-489): 3.26e-60: 214: 14.91		RAB5A_HUMAN (10-224): 2.26e-49: 162: 41.28
+	Hs
		895371 RIN2_HUMAN (140-489): 3.26e-60: 214: 14.91		RAB5B_HUMAN (10-224): 8.75e-47: 155: 38.61