HitPredict

Interactor 1: P3C2B (O00750)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)
Gene: PIK3C2B

Interactor 2: SH3Y1 (Q96HL8)
SH3 domain-containing YSC84-like protein 1
Gene: SH3YL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035091 - phosphatidylinositol binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1634 Hs			1 342
+	Hs
		135775 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12
+	Hs
		135796 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		ITSN2_HUMAN (128-341): 1.08e-15: 80.2: 14.75
+	Hs
		135781 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		ITSN1_HUMAN (169-340): 1.25e-14: 77.2: 12.77
+	Mm
		93763 E9QAN8_MOUSE (1-1632): 0: 1945: 93.69		ITSN1_MOUSE (92-341): 4.75e-17: 84.5: 15.58
+	Dm
		993186 Q7JNX6_DROME (177-1631): 0: 1073: 35.27		GRAP_DROME (288-340): 5.58e-18: 83.2: 49.06
+	Hs
		536568 PK3CA_HUMAN (307-1344): 0: 804: 25.46		HCLS1_HUMAN (147-341): 3.34e-27: 113: 18.88
+	Hs
		787202 PK3CA_HUMAN (307-1344): 0: 804: 25.46		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12
+	Hs
		787365 PK3CB_HUMAN (294-1341): 0: 796: 24.71		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12
+	Hs
		1031523 ATM_HUMAN (794-1363): 1.78e-105: 377: 14.20		SRC8_HUMAN (151-341): 4.67e-29: 119: 14.84
+	Hs
		924472 PRKDC_HUMAN (837-1294): 2.19e-89: 326: 14.59		GRB2_HUMAN (284-340): 1.1e-25: 104: 49.12