Protein: RCL1
rRNA processing protein RCL1 (RNA 3'-terminal phosphate cyclase-like protein 1)

Gene: RCL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 136
UniProt ID: Q08096

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 - endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004521 - RNA endonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1061642

BMS1
Ribosome biogenesis protein BMS1

10

2

Small-scale

0.756

High

1061636

RCL1
rRNA processing protein RCL1

2

0

High-throughput

0.736

High

798330

ENP1
Essential nuclear protein 1

8

0

Small-scale

0.714

High

1046061

DHR1
Probable ATP-dependent RNA helicase DHR1

6

0

Small-scale

0.695

High

844639

UTP10
U3 small nucleolar RNA-associated protein 10

5

0

High-throughput

0.678

High

1055437

RRP9
Ribosomal RNA-processing protein 9

3

2

High-throughput

0.656

High

1061656

NOP14
Nucleolar complex protein 14

3

1

High-throughput

0.656

High

1055499

NOC4
Nucleolar complex protein 4

4

0

Small-scale

0.648

High

678474

PWP2
Periodic tryptophan protein 2

3

1

Small-scale

0.640

High

763639

UTP20
U3 small nucleolar RNA-associated protein 20

3

0

High-throughput

0.628

High

1061645

RRP6
Exosome complex exonuclease RRP6

3

0

High-throughput

0.613

High

806587

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.585

High

826221

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

1059611

NOP6
Nucleolar protein 6

2

0

High-throughput

0.585

High

1053525

UTP21
U3 small nucleolar RNA-associated protein 21

2

3

Small-scale

0.584

High

1056487

UTP4
U3 small nucleolar RNA-associated protein 4

2

2

Small-scale

0.584

High

1061653

NOP58
Nucleolar protein 58

2

1

High-throughput

0.584

High

818354

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

0

Small-scale

0.576

High

1050186

RRP5
rRNA biogenesis protein RRP5

2

0

Small-scale

0.569

High

513253

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.559

High

673242

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

677589

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

836207

DIM1
Dimethyladenosine transferase

2

0

Small-scale

0.559

High

923992

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

924647

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.559

High

1046807

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

546518

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

525348

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.533

High

585393

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.515

High

1037774

RNT1
Ribonuclease 3

1

0

High-throughput

0.493

High

722313

XPO1
Exportin-1

1

3

High-throughput

0.489

High

149983

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

455293

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

512685

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513918

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.479

High

632752

DBP4
ATP-dependent RNA helicase HCA4

1

1

High-throughput

0.479

High

747056

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.479

High

802915

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.479

High

804758

RRP4
Exosome complex component RRP4

1

1

High-throughput

0.479

High

852616

ROK1
ATP-dependent RNA helicase ROK1

1

1

High-throughput

0.479

High

863144

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

864532

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.479

High

918903

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

1039866

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

1042250

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

1045116

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.479

High

1051717

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

1053122

UTP13
U3 small nucleolar RNA-associated protein 13

1

3

High-throughput

0.479

High

1056317

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

1061647

UTP12
U3 small nucleolar RNA-associated protein 12

1

3

High-throughput

0.479

High

1061648

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

1061650

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

1061651

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

436202

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442139

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

512167

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

514864

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

672965

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674867

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689696

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

700303

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

Small-scale

0.458

High

710015

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

735198

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

753619

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

754346

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

758418

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

782115

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

804966

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

808321

RRP8
25S rRNA

1

0

High-throughput

0.458

High

817645

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.458

High

823399

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

825091

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825571

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

865184

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

871067

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

871133

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

874562

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

918840

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

919022

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

919185

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

923264

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

925208

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

1036421

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

1046265

UTP15
U3 small nucleolar RNA-associated protein 15

1

0

High-throughput

0.458

High

1051168

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

1054546

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1054899

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

1060758

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1061637

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.458

High

1061638

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1061640

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1061643

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

1061644

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

1061652

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

1061654

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1061655

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

1061657

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

819965

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

410367

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433878

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

963763

H3
Histone H3

1

1

High-throughput

0.437

High

1061641

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

782467

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.426

High

527843

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

742534

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

393430

HSP82
ATP-dependent molecular chaperone HSP82

2

0

High-throughput

0.298

High

1061649

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.288

High

1027317

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.279

Low

1044083

VHS1
Serine/threonine-protein kinase VHS1

1

0

High-throughput

0.279

Low

382385

H4
Histone H4

1

0

High-throughput

0.249

Low

383923

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

419894

H2A2
Histone H2A.2

1

0

High-throughput

0.249

Low

436536

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.249

Low

503273

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504445

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

680620

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

0

High-throughput

0.249

Low

708364

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

780063

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

792280

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

795242

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

802419

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

812717

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

918477

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

1033599

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1044793

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

1053989

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1054857

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1059371

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

1061639

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1061646

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.249

Low

743484

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.238

Low

671726

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

752812

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

863768

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

893240

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025