HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005794 - Golgi apparatus GO:0006468 - protein phosphorylation GO:0046777 - protein autophosphorylation GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 1503
+	Hs
		433891 LYN_HUMAN (1-512): 0: 611: 100.00		MINK1_HUMAN (116-1179): 3.76e-138: 461: 11.73
+	Hs
		433770 LYN_HUMAN (1-512): 0: 611: 100.00		ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30
+	Hs
		442789 HCK_HUMAN (1-512): 0: 595: 70.70		ABL2_HUMAN (68-1028): 5.61e-138: 457: 15.48
+	Hs
		442833 HCK_HUMAN (1-512): 0: 595: 70.70		ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30
+	Hs
		296394 LYN_HUMAN (1-512): 0: 611: 100.00		STK10_HUMAN (120-983): 1.43e-124: 415: 17.57
+	Hs
		433573 LYN_HUMAN (1-512): 0: 611: 100.00		FGFR2_HUMAN (33-454): 4.84e-123: 406: 20.31
+	Hs
		433760 LYN_HUMAN (1-512): 0: 611: 100.00		FAK2_HUMAN (66-696): 3.04e-118: 398: 17.76
+	Hs
		337315 HCK_HUMAN (1-512): 0: 595: 70.70		ABL1_HUMAN (84-931): 1.76e-117: 399: 18.90
+	Hs
		433602 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA3_HUMAN (55-410): 3.26e-109: 373: 22.84
+	Hs
		433601 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA2_HUMAN (81-437): 8.15e-109: 371: 24.31
+	Hs
		433662 LYN_HUMAN (1-512): 0: 611: 100.00		EPHA4_HUMAN (62-440): 1.33e-108: 371: 23.56
+	Rn
		989763 LYN_RAT (1-512): 0: 612: 96.09		LYN_RAT (86-421): 1.95e-109: 358: 21.89
+	Hs
		433522 LYN_HUMAN (1-512): 0: 611: 100.00		LYN_HUMAN (86-421): 2.69e-109: 358: 22.19
+	Hs
		411611 LCK_HUMAN (1-512): 0: 582: 63.62		EPHA2_HUMAN (81-437): 8.15e-109: 371: 24.31
+	Hs
		433530 HCK_HUMAN (1-512): 0: 595: 70.70		LYN_HUMAN (86-421): 2.69e-109: 358: 22.19
+	Hs
		411553 LCK_HUMAN (1-512): 0: 582: 63.62		LYN_HUMAN (86-421): 2.69e-109: 358: 22.19
+	Hs
		384114 LYN_HUMAN (1-512): 0: 611: 100.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		433523 LYN_HUMAN (1-512): 0: 611: 100.00		IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33
+	Hs
		433631 LYN_HUMAN (1-512): 0: 611: 100.00		TEC_HUMAN (123-410): 1.39e-31: 134: 30.61
+	Hs
		433742 LYN_HUMAN (1-512): 0: 611: 100.00		PTK7_HUMAN (28-403): 9.63e-31: 134: 29.05