HitPredict

Interactor 1: LAMP3 (Q9UQV4)
Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)
Gene: LAMP3

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 34079125, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 1785
+	Hs
		527918 LAMP2_HUMAN (16-415): 1.55e-144: 419: 18.47		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		527919 LAMP2_HUMAN (16-415): 1.55e-144: 419: 18.47		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		1357948 LAMP3_HUMAN (1-416): 1.85e-139: 406: 100.00		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		1348512 LAMP3_HUMAN (1-416): 1.85e-139: 406: 100.00		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		507273 LAMP1_HUMAN (7-416): 5.41e-138: 402: 21.23		PSD3_HUMAN (202-1074): 2.97e-179: 571: 13.83
+	Hs
		527513 LAMP2_HUMAN (16-415): 1.55e-144: 419: 18.47		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88
+	Hs
		1136965 LAMP3_HUMAN (1-416): 1.85e-139: 406: 100.00		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88