HitPredict

Interactor 1: PSDE (Q9V3H2)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory complex subunit p37B) (26S proteasome regulatory subunit rpn11) (Yippee-interacting protein 5)
Gene: Rpn11

Interactor 2: PSB4 (Q9VNA5)
Proteasome subunit beta type-4 (Proteasome subunit beta type-7)
Gene: Prosbeta7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 308 Dm			1 268
+	Dm
		574029 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		PSA4_DROME (33-268): 1.36e-78: 240: 14.34
+	Dm
		1278634 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		PSA5_DROME (33-266): 1.46e-77: 236: 17.00
+	Dm
		611650 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		PSA71_DROME (32-265): 1.61e-77: 236: 12.50
+	Hs
		130644 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSA7_HUMAN (33-265): 2.53e-82: 248: 12.55
+	Hs
		130749 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSA4_HUMAN (32-265): 3.42e-79: 241: 13.33
+	Hs
		130824 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSA6_HUMAN (28-265): 1.4e-78: 239: 17.55
+	Hs
		130755 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSB4_HUMAN (12-268): 4.95e-78: 238: 38.91
+	Hs
		130754 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSA5_HUMAN (33-266): 7.04e-78: 237: 17.96
+	Dm
		1178949 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		Q7K148_DROME (56-252): 1.88e-69: 217: 20.31
+	Mm
		192889 PSDE_MOUSE (18-308): 2.22e-103: 306: 89.69		PSB4_MOUSE (13-268): 7.14e-77: 235: 40.23
+	Dm
		1358675 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		Q9VUJ1_DROME (60-260): 6.76e-69: 215: 19.40
+	Sp
		675389 RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21		PSB5_SCHPO (24-268): 6.17e-75: 230: 18.70
+	Hs
		130757 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSB5_HUMAN (15-247): 2.34e-71: 221: 18.03
+	Hs
		131052 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSB7_HUMAN (23-260): 1.37e-69: 217: 19.58
+	Hs
		130736 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSB1_HUMAN (22-248): 5.77e-66: 207: 19.66
+	Dm
		771410 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		PSB1_DROME (29-251): 2.59e-58: 187: 23.08
+	Sp
		195130 RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21		PSB1_SCHPO (53-250): 2.44e-65: 205: 17.17
+	Dm
		1358671 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		Q9VJJ0_DROME (59-257): 1.07e-21: 91.3: 19.60
+	Dm
		47612 PSDE_DROME (1-308): 1.38e-110: 324: 100.00		A0AQH0_DROME (50-248): 6.38e-21: 89.8: 16.08
+	Hs
		130798 PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69		PSB2_HUMAN (60-247): 7.94e-21: 89: 20.75