HitPredict

Interactor 1: Q9VBI3 (Q9VBI3)
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a)
Gene: Vps2

Interactor 2: Q9VN02 (Q9VN02)
Charged multivesicular body protein 3 (Chromatin-modifying protein 3)
Gene: Vps24

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	14605208, 22036573
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0045324 - late endosome to vacuole transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 256 Dm			1 223
+	At
		1013164 VPS2A_ARATH (1-255): 6.41e-47: 157: 45.49		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	Hs
		208872 CHM2A_HUMAN (1-190): 1.75e-41: 143: 77.90		CHMP3_HUMAN (1-223): 7.31e-52: 168: 57.40
+	At
		1322583 VPS2A_ARATH (1-255): 6.41e-47: 157: 45.49		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	At
		1013158 VP601_ARATH (1-229): 2.46e-42: 146: 16.46		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	Hs
		1357921 CHM2B_HUMAN (7-212): 4.34e-40: 139: 33.50		CHMP3_HUMAN (1-223): 7.31e-52: 168: 57.40
+	Sc
		732840 DID4_YEAST (2-256): 6.75e-41: 142: 39.45		DID4_YEAST (3-222): 4.31e-50: 164: 21.78
+	At
		98407 F4JXR3_ARATH (1-229): 1.03e-44: 153: 14.55		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	At
		1013141 VPS2B_ARATH (3-213): 1.29e-38: 136: 31.82		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	At
		1013147 CHM1A_ARATH (13-215): 5.66e-39: 136: 20.69		VPS2B_ARATH (1-222): 9.82e-50: 163: 24.32
+	At
		1322582 VP601_ARATH (1-229): 2.46e-42: 146: 16.46		VP241_ARATH (7-223): 1.08e-45: 153: 40.72
+	Dm
		1362010 Q9VBI3_DROME (1-256): 2.69e-43: 149: 100.00		Q9VRJ5_DROME (2-209): 1.68e-44: 149: 27.40
+	Hs
		208801 CHM2A_HUMAN (1-190): 1.75e-41: 143: 77.90		CHM2A_HUMAN (3-222): 2.42e-45: 152: 22.73
+	Hs
		1357919 CHM2B_HUMAN (7-212): 4.34e-40: 139: 33.50		CHM2B_HUMAN (9-204): 2.59e-44: 149: 22.45
+	Sc
		732538 DID4_YEAST (2-256): 6.75e-41: 142: 39.45		VPS24_YEAST (10-223): 2.51e-42: 144: 30.23
+	Dm
		1279485 Q9VBI3_DROME (1-256): 2.69e-43: 149: 100.00		Q95SH2_DROME (23-222): 2.92e-38: 133: 16.50
+	At
		1013166 VPS2B_ARATH (3-213): 1.29e-38: 136: 31.82		CHM1B_ARATH (22-217): 4.85e-40: 137: 16.84
+	Dm
		1279488 Q9VRJ5_DROME (2-213): 4.73e-39: 136: 32.08		Q95SH2_DROME (23-222): 2.92e-38: 133: 16.50
+	Sc
		732857 DID4_YEAST (2-256): 6.75e-41: 142: 39.45		DID2_YEAST (22-222): 4.04e-32: 117: 12.44