HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: PLAP (Q9Y263)
Phospholipase A-2-activating protein (PLA2P) (PLAP)
Gene: PLAA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34591612
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 795
+	Hs
		749312 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		WDR5_HUMAN (324-622): 4.79e-28: 117: 12.33
+	Hs
		725375 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		COPB2_HUMAN (316-579): 2.4e-17: 88.9: 7.90
+	Hs
		749840 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBL1R_HUMAN (314-466): 1.88e-16: 85.1: 11.39
+	Hs
		1266889 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		NLE1_HUMAN (5-138): 2.15e-29: 124: 18.52
+	Hs
		1243282 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		FBW1B_HUMAN (3-179): 1.11e-34: 141: 22.34
+	Hs
		585027 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		FBXW7_HUMAN (142-456): 2.86e-61: 221: 19.00
+	Hs
		725498 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		COPB2_HUMAN (316-579): 2.4e-17: 88.9: 7.90
+	Hs
		1019346 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		FBXW7_HUMAN (142-456): 2.86e-61: 221: 19.00
+	Hs
		585096 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		FBW1A_HUMAN (138-358): 8.68e-41: 160: 18.03
+	Hs
		585092 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		FBW1B_HUMAN (3-179): 1.11e-34: 141: 22.34
+	Hs
		903462 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		WDR5_HUMAN (324-622): 4.79e-28: 117: 12.33
+	Hs
		921711 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		GBB2_HUMAN (167-416): 5.33e-30: 123: 12.31