HitPredict

Interactor 1: Q9VPW2 (Q9VPW2)
Cysteine protease (EC 3.4.22.-)
Gene: Atg4a

Interactor 2: Q9W2S2 (Q9W2S2)
Autophagy-related 8a, isoform A (LD05816p)
Gene: Atg8a

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0005829 - cytosol GO:0006914 - autophagy GO:0010506 - regulation of autophagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Dm			1 121
+	Dm
		1179054 Q9VPW2_DROME (1-411): 0: 664: 100.00		Q7K1J3_DROME (1-116): 1.37e-54: 169: 82.76
+	Dm
		1364631 Q9VPW2_DROME (1-411): 0: 664: 100.00		Q9VEG5_DROME (1-116): 1.13e-54: 168: 82.76
+	Dm
		114224 M9PBM3_DROME (1-411): 0: 658: 99.76		Q9VEG5_DROME (1-116): 1.13e-54: 168: 82.76
+	Hs
		891370 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		GBRL2_HUMAN (1-117): 2.59e-58: 177: 57.27
+	Hs
		306368 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		GBRAP_HUMAN (1-117): 1.93e-57: 175: 91.45
+	Hs
		1328075 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		GBRL1_HUMAN (1-116): 1.15e-56: 173: 85.35
+	Hs
		891248 ATG4A_HUMAN (13-355): 2.75e-156: 448: 40.75		GBRL2_HUMAN (1-117): 2.59e-58: 177: 57.27
+	Hs
		306253 ATG4A_HUMAN (13-355): 2.75e-156: 448: 40.75		GBRAP_HUMAN (1-117): 1.93e-57: 175: 91.45
+	Hs
		1264549 ATG4A_HUMAN (13-355): 2.75e-156: 448: 40.75		GBRL1_HUMAN (1-116): 1.15e-56: 173: 85.35
+	Mm
		1206409 ATG4B_MOUSE (38-354): 4.16e-164: 467: 43.55		MLP3A_MOUSE (5-117): 1.71e-45: 145: 31.30
+	Hs
		1315816 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		MLP3C_HUMAN (5-116): 4.61e-45: 145: 37.72
+	Hs
		1330686 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		MLP3A_HUMAN (5-117): 1.71e-45: 145: 31.30
+	Hs
		1326231 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		MLP3B_HUMAN (2-117): 1.61e-44: 142: 30.51
+	Hs
		61909 ATG4B_HUMAN (38-354): 7.28e-163: 464: 44.13		MP3B2_HUMAN (2-117): 1.07e-43: 140: 29.66
+	Hs
		1264550 ATG4A_HUMAN (13-355): 2.75e-156: 448: 40.75		MLP3A_HUMAN (5-117): 1.71e-45: 145: 31.30
+	Hs
		1264548 ATG4A_HUMAN (13-355): 2.75e-156: 448: 40.75		MLP3B_HUMAN (2-117): 1.61e-44: 142: 30.51
+	Hs
		891203 ATG4D_HUMAN (48-366): 1.06e-140: 411: 32.97		GBRL2_HUMAN (1-117): 2.59e-58: 177: 57.27
+	Ce
		111920 ATG41_CAEEL (9-352): 1.6e-142: 416: 35.11		LGG1_CAEEL (1-116): 4.45e-56: 171: 85.35
+	Hs
		306219 ATG4D_HUMAN (48-366): 1.06e-140: 411: 32.97		GBRAP_HUMAN (1-117): 1.93e-57: 175: 91.45
+	Ce
		111921 ATG41_CAEEL (9-352): 1.6e-142: 416: 35.11		LGG2_CAEEL (4-116): 1.3e-39: 130: 32.17