HitPredict

Interactor 1: CDC37 (O02108)
Probable Hsp90 co-chaperone cdc37 (Cell division cycle-related protein 37) (Hsp90 chaperone protein kinase-targeting subunit)
Gene: cdc-37

Interactor 2: HSP90 (Q18688)
Heat shock protein 90 (Abnormal dauer formation protein 21)
Gene: daf-21

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.941

The method score is based on:

Property Details
Experiments 23569206, 26511315, 27620500, 14704431, 18692475, unassigned701
Identification Methods pull down, two hybrid, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC37_M~HSP90, CDC37_N~HSP90
Common GO terms GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0008287 - protein serine/threonine phosphatase complex
GO:0022417 - protein maturation by protein folding
GO:0050821 - protein stabilization
and 3 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 370
Ce

1 702
+ Hs
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Sc
+ Sc
+ Hs

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Last updated: 15 Jul 2024