Protein: ELL
RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)

Gene: ELL
Organism: Homo sapiens
Interactions: 62
UniProt ID: P55199

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001701 - in utero embryonic development
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936615

EAF1
ELL-associated factor 1

9

5

Small-scale

0.973

High

936626

AFF4
AF4/FMR2 family member 4

4

12

High-throughput

0.903

High

936612

EAF2
ELL-associated factor 2

4

5

Small-scale

0.878

High

936621

ELL3
RNA polymerase II elongation factor ELL3

3

2

High-throughput

0.861

High

908266

AFF1
AF4/FMR2 family member 1

2

11

Small-scale

0.754

High

839873

AF9
Protein AF-9

6

10

Small-scale

0.726

High

485592

RU2A
U2 small nuclear ribonucleoprotein A'

4

1

High-throughput

0.691

High

897677

CDK9
Cyclin-dependent kinase 9

4

4

Small-scale

0.686

High

188226

HDAC3
Histone deacetylase 3

2

1

Small-scale

0.653

High

936620

DEN2D
DENN domain-containing protein 2D

3

0

High-throughput

0.638

High

413485

P53
Cellular tumor antigen p53

2

2

Small-scale

0.631

High

871909

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

936599

ICE2
Little elongation complex subunit 2

2

2

Small-scale

0.628

High

936630

ICE1
Little elongation complex subunit 1

2

2

Small-scale

0.628

High

936614

SNF8
Vacuolar-sorting protein SNF8

2

0

Small-scale

0.618

High

936589

ENL
Protein ENL

2

10

Small-scale

0.611

High

936607

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

Small-scale

0.598

High

936598

USPL1
SUMO-specific isopeptidase USPL1

2

0

Small-scale

0.585

High

251551

CCNT1
Cyclin-T1

2

5

Small-scale

0.584

High

936587

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.537

High

289967

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.536

High

335975

MED26
Mediator of RNA polymerase II transcription subunit 26

1

2

High-throughput

0.536

High

911523

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.536

High

936588

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.536

High

936600

CTR9
RNA polymerase-associated protein CTR9 homolog

1

2

High-throughput

0.536

High

936602

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.536

High

936613

DYL2
Dynein light chain 2, cytoplasmic

1

2

High-throughput

0.536

High

936618

SIKE1
Suppressor of IKBKE 1

1

1

High-throughput

0.536

High

936624

FGOP2
FGFR1 oncogene partner 2

1

1

High-throughput

0.536

High

936605

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.515

High

936592

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

936616

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

936623

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

507732

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

887870

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.501

High

936591

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.501

High

503563

TFPT
TCF3 fusion partner

1

0

Small-scale

0.501

High

936606

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.489

High

936608

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.489

High

936594

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

936603

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

2

High-throughput

0.479

High

936611

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

936625

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

936628

HDAC5
Histone deacetylase 5

1

2

Small-scale

0.479

High

936627

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

Small-scale

0.460

High

459516

PROF1
Profilin-1

1

0

Small-scale

0.458

High

606503

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

897184

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

936590

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

936593

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.458

High

936595

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

936596

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

936597

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

936604

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

936610

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

936617

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

936619

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

936629

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

936609

CAMKV
CaM kinase-like vesicle-associated protein

3

0

High-throughput

0.345

High

936586

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.279

Low

936601

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

936622

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025