HitPredict

Interactor 1: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: UBP3 (Q9Y6I4)
Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3)
Gene: USP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31056254
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 522 Hs			1 520
+	Hs
		271228 TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		1356323 TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00		UBP21_HUMAN (117-516): 2.18e-104: 325: 28.57
+	Hs
		271081 TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		1020743 TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85		U17L2_HUMAN (91-519): 6.03e-94: 297: 22.56
+	Hs
		1024693 TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18		U17L2_HUMAN (91-519): 6.03e-94: 297: 22.56
+	Hs
		271082 TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		1257048 TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00		UBP33_HUMAN (3-277): 2.05e-21: 100: 28.77
+	Hs
		1024451 TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00		UBP4_HUMAN (160-345): 5.47e-16: 83.2: 29.74
+	Hs
		271032 RO52_HUMAN (64-403): 5.77e-45: 166: 14.97		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		271027 TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Mm
		715072 TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93		UBP4_MOUSE (160-345): 1.75e-16: 84.7: 29.74
+	Hs
		271136 TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		271189 TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11		UBP2_HUMAN (82-516): 3.57e-111: 344: 30.32
+	Hs
		1318717 TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11		UBP21_HUMAN (117-516): 2.18e-104: 325: 28.57
+	Hs
		1019375 TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59		UBP36_HUMAN (98-519): 1.5e-94: 312: 25.06
+	Hs
		777079 RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33		UBP8_HUMAN (50-517): 1.53e-105: 342: 27.20
+	Mm
		1193545 RNF41_MOUSE (55-177): 2.68e-17: 84.9: 33.33		UBP8_MOUSE (50-517): 3.44e-105: 340: 27.41
+	Hs
		1020630 TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85		UBP4_HUMAN (160-345): 5.47e-16: 83.2: 29.74
+	Hs
		1024331 TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61		UBP4_HUMAN (160-345): 5.47e-16: 83.2: 29.74
+	Hs
		584941 RO52_HUMAN (64-403): 5.77e-45: 166: 14.97		UBP4_HUMAN (160-345): 5.47e-16: 83.2: 29.74