Protein: PAN3
PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)

Gene: PAN3
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q58A45

Gene Ontology (top 5):
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1197505

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

5

8

Small-scale

0.927

High

550315

PABP1
Polyadenylate-binding protein 1

6

8

Small-scale

0.739

High

1201706

ASF1A
Histone chaperone ASF1A

3

1

High-throughput

0.667

High

1201701

ASF1B
Histone chaperone ASF1B

3

1

High-throughput

0.662

High

1201699

TNR6C
Trinucleotide repeat-containing gene 6C protein

3

8

Small-scale

0.656

High

1201704

TNR6B
Trinucleotide repeat-containing gene 6B protein

2

6

Small-scale

0.639

High

1201687

TNR6A
Trinucleotide repeat-containing gene 6A protein

2

8

Small-scale

0.621

High

348866

CLIC3
Chloride intracellular channel protein 3

1

2

High-throughput

0.536

High

581540

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.536

High

1150429

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

High-throughput

0.536

High

1201690

PABP5
Polyadenylate-binding protein 5

1

8

High-throughput

0.536

High

1201703

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.536

High

1201685

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1201705

CLC11
C-type lectin domain family 11 member A

1

2

High-throughput

0.489

High

336440

SVIL
Supervillin

1

5

Small-scale

0.481

High

172895

XPO1
Exportin-1

1

11

High-throughput

0.479

High

223103

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

241886

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

331031

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

413963

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

684263

DDX6
Probable ATP-dependent RNA helicase DDX6

1

9

High-throughput

0.479

High

688255

TTP
mRNA decay activator protein ZFP36

1

2

High-throughput

0.479

High

691070

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

695629

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

713791

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

10

High-throughput

0.479

High

730636

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

875683

PRC2A
Protein PRRC2A

1

8

High-throughput

0.479

High

904806

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

966405

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

1049360

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1101985

PABP4
Polyadenylate-binding protein 4

1

8

High-throughput

0.479

High

1122071

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.479

High

1140379

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1165446

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

9

High-throughput

0.479

High

1201680

RC3H1
Roquin-1

1

2

High-throughput

0.479

High

1201684

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.479

High

1201688

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

1201689

CELF1
CUGBP Elav-like family member 1

1

8

High-throughput

0.479

High

1201691

BICD1
Protein bicaudal D homolog 1

1

9

High-throughput

0.479

High

1201694

LZTS2
Leucine zipper putative tumor suppressor 2

1

17

High-throughput

0.479

High

1201695

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

8

High-throughput

0.479

High

1201696

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.479

High

1201697

RC3H2
Roquin-2

1

7

High-throughput

0.479

High

1201698

MOV10
Helicase MOV-10

1

4

High-throughput

0.479

High

1201700

ANLN
Anillin

1

2

High-throughput

0.479

High

1201707

NINL
Ninein-like protein

1

10

High-throughput

0.479

High

1201710

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

176484

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

1201679

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1201681

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1201683

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1201702

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.458

High

1201708

R3HD2
R3H domain-containing protein 2

1

0

High-throughput

0.458

High

768355

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1201682

SYNE3
Nesprin-3

1

11

High-throughput

0.437

High

299227

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

657592

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

1201692

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1201693

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.249

Low

1201709

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.249

Low

1201686

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025