Interactor 1: EME1 (Q96AY2)
Structure-specific endonuclease subunit EME1 (Crossover junction endonuclease EME1) (Essential meiotic structure-specific endonuclease 1) (MMS4 homolog) (hMMS4)
Gene: EME1
Interactor 2: MUS81 (Q96NY9)
Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81) (MUS81 endonuclease homolog)
Gene: MUS81
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 29738624, 14617801, 19596236, 19363487, 25224045, 28514442, 25319828, 27354282, 18413719, 12721304, 28575661, 33961781, 21962513, 19017809, 17289582, 12686547, unassigned3799, 24733841 |
| Identification Methods | pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, gal4 vp16 complementation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | EME1-MUS81_C~EME1-MUS81_C, ERCC4~ERCC4 |
| Common GO terms | GO:0000712 - resolution of meiotic recombination intermediates GO:0003677 - DNA binding GO:0004519 - endonuclease activity GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 9 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Mm |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Dm | |
 |
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
